Concept
Médicament générique
Publications associées (43)
Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations
Ex-vivo drug sensitivity screening (DSS) allows the prediction of cancer treatment effectiveness in a personalized fashion. However, it only provides a readout on mixtures of cells, potentially occulting important information on clinically relevant cell su ...
EPFL2024Therapeutic approaches against coronaviruses acute respiratory syndrome
Francesco Stellacci, Camilla Servidio
Coronaviruses represent global health threat. In this century, they have already caused two epidemics and one serious pandemic. Although, at present, there are no approved drugs and therapies for the treatment and prevention of human coronaviruses, several ...
JOHN WILEY & SONS LTD2021Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
Florence Pojer, Kelvin Ka Ching Lau, Oliver Hantschel, Grégory La Sala
The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere ...
20205-Fluorouracil Release from Chitosan-Based Matrix. Experimental and Theoretical Aspects
A series of four drug release formulations based on 5-fluorouracil encapsulated into a chitosan-based matrix were prepared by in situ hydrogelation with 3,7-dimethyl-2,6-octadienal. The formulations were investigated from structural and morphological aspec ...
2020Advancing Drug Discovery via Artificial Intelligence
Horst Vogel, Thamani Dahoun, Shuguang Yuan
Drug discovery and development are among the most important translational science activities that contribute to human health and wellbeing. However, the development of a new drug is a very complex, expensive, and long process which typically costs 2.6 bill ...
ELSEVIER SCIENCE LONDON2019