Concept
Transplantation cardiaque
Publications associées (65)
Whole-heart electromechanical simulations using Latent Neural Ordinary Differential Equations
Alfio Quarteroni, Francesco Regazzoni, Luca Dede'
Cardiac digital twins provide a physics and physiology informed framework to deliver personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to adoption due to their extensive computational costs. Artificial Intelligence-b ...
Nature Portfolio2024Mechanisms and functions of protein S-acylation
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento R De Mesquita
Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...
Berlin2024The role of computational methods in cardiovascular medicine: a narrative review
Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani
Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...
Ame Publishing Company2024Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort
Jacques Fellay, Christian Axel Wandall Thorball
Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic risk scores (PRS) in the prediction of pre-transplant T2DM and post-transplant diabetes mellitus ( ...
Lausanne2023lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications
Alfio Quarteroni, Luca Dede', Marco Fedele
Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional regime of blood flow in the heart, and the strong mutual influence between the ...
Amsterdam2023A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart
We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory system. Our mod ...
WILEY2023Causal inference with recurrent and competing events
Mats Julius Stensrud, Pal Christie Ryalen, Matias Janvin
Many research questions concern treatment effects on outcomes that can recur several times in the same individual. For example, medical researchers are interested in treatment effects on hospitalizations in heart failure patients and sports injuries in ath ...
SPRINGER2023