Concept
Cycle de l'urée
Publications associées (47)
Optical Urea Sensing in Sweat for Kidney Healthcare by Sensitive and Selective Non-enhanced Raman Spectroscopy
Christian Enz, Sandro Carrara, Assim Boukhayma, Ata Jedari Golparvar, Mattia Petrelli
Sweat biomarker analysis has attracted much interest in applications ranging from sports to wearable healthcare. Among all the sweat biomolecules, abnormal urea levels have been linked to several complications, particularly renal dysfunction. Here, we repo ...
SPIE-INT SOC OPTICAL ENGINEERING2023Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
Vassily Hatzimanikatis, Maria Masid Barcon, Ming Yang
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related ...
NATURE PORTFOLIO2022Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by (13)C Magnetic Resonance Spectroscopy
Rolf Gruetter, João Miguel das Neves Duarte, Sarah Catherine Sonnay, Freya-Merret Girault
Type 2 diabetes (T2D) is associated with deterioration of brain structure and function. Here, we tested the hypothesis that T2D induces a reorganization of the brain metabolic networks that support brain function. For that, alterations of neuronal and glia ...
2019Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex
Rolf Gruetter, Gregor Rainer, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay, Anne Catherine Clerc
Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...
Wiley-Blackwell2018Renal metabolism of hyperpolarized [1-13C]aspartate
Hikari Ananda Infinity Yoshihara
Aspartic acid is involved in several central metabolic pathways, including gluconeogenesis, the urea cycle, de novo nucleotide synthesis, the malate-aspartate shuttle, and via transmination the TCA cycle. The conversion in vivo of hyperpolarized [1-13C]pyr ...
2018Effect of Chaotropes on the Transfer of Ions and Dyes across the Liquid–Liquid Interface
Hubert Girault, Pekka Eero Peljo, Evgeny Smirnov, Grégoire Clément Gschwend, Lucie Josette Renée Rivier, Elena Vladimirova
Chaotropes such as urea can break the structure of water, weakening the hydrophobic effect and reducing aggregation. Here, we investigated how the addition of urea affects the transfer of ions and cationic dyes across the interface between immiscible elect ...
2018Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen
Elise Marie Catherine Vinckenbosch
Magnetic resonance at ultra-high field increases signal and spectral dispersion. In this thesis, I use those characteristics to investigate three different subjects in 13C spectroscopy, hyperpolarized methods and chemical exchange saturation transfer (CEST ...
EPFL2018Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine
Rolf Gruetter, Cristina Ramona Cudalbu, Dmitri Firsov, Hikari Ananda Infinity Yoshihara
Detoxification of ammonia by the urea cycle and maintenance of glucose homeostasis by gluconeogenesis are two critical functions of the liver. The bile duct ligation (BDL) model of cirrhosis was used to test the ability of hyperpolarized [6-13C]arginine an ...
2018On the swelling behavior of shallow Opalinus Clay shale
Lyesse Laloui, Alessio Ferrari, Eleonora Crisci
The Opalinus Clay shale is the selected geological formation for the construction of a deep geological repository in Switzerland. The geomaterial will experience cyclic drying and wetting paths during different stages of the repository lifetime. The shale, ...
2018Energy metabolism in the rat cortex under thiopental anaesthesia measured
Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay
Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...
Wiley-Blackwell2017