Concept

Voie d'administration

Publications associées (86)

Carbon Monoxide-Releasing Micelles for Immunotherapy

Eleonora Simeoni, Jeffrey Alan Hubbell, Jutta Christine Wandrey, Urara Hasegawa

With the discovery of important biological roles of carbon monoxide (CO), the use of this gas as a therapeutic agent has attracted attention. However, the medical application of this gas has been hampered by the complexity of the administration method. To ...

American Chemical Society2010

Vascular effects induced by anti-VEGF agents in the CAM model: Effect of the DMSO

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

The chicken embryo's chorioallantoic membrane (CAM) is widely used as an in vivo model to study the vascular effects induced by agents administrated topically or intravenously. Hence, in the vascular plexus of this respiratory membrane, angiogenic and anti ...

2009

Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: Physicochemical and magnetic properties, in vitro and in vivo drug release

Heinrich Hofmann, Pierre Stadelmann, Pierre Burdet

Compared with traditional drug solutions or suspensions, polymeric microparticles represent a valuable means to achieve controlled and prolonged drug delivery into joints, but still suffer from the drawback of limited retention duration in the articular ca ...

2009

Neuroprotective role of lactate after cerebral ischemia

Rolf Gruetter, Pierre Magistretti, Hongxia Lei, Jonathan Thevenet

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective e ...

2009

Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery

Heinrich Hofmann, Alke Fink, Olivier Jordan

Objective: Intra-articular drug delivery systems still suffer from too short-lasting effects. Magnetic particles retained in the joint using an external magnetic field might prolong the local release of an anti-inflammatory drug. For the purpose, superpara ...

Taylor & Francis2008

Using drug delivery systems to enhance joint replacement

Dominique Pioletti

Why do we need to improve the outcome of orthopedic implants? What is the clinical situation for orthopedic implant used as drug delivery system? Is the research for orthopedic drug delivery system advanced enough to translate it to clinical applications? ...

CRC Press2008

Fluid mechanics of intrathecal drug delivery

Radboud Michael Nelissen

The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a ...

EPFL2008

Training and evaluation of lumbar punctures in a VR-environment using a 6DOF haptic device

Friedhelm Christoph Hummel

A virtual reality system for the training of the lumbar puncture intervention is presented. We use a haptic device with six degrees of freedom (6DOF) to feedback forces that resist needle insertion and rotation. An improved haptic volume rendering approach ...

IOS Press2008

Induction of tau pathology by intracerebral infusion of amyloid-beta-containing brain extract and by amyloid-beta deposition in APP x tau transgenic mice

Tristan Bolmont

Alzheimer's disease presents morphologically with senile plaques, primarily made of extracellular amyloid-beta (A beta) deposits, and neurofibrillary lesions, which consist of intracellular aggregates of hyper-phosphorylated tau protein. To study the in vi ...

American Society for Investigative Pathology2007

Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions

Matthias Lütolf, Jeffrey Alan Hubbell, Martin Ehrbar

We present polymeric hydrogel biomaterials that are biomimetic both in their synthesis and degradation. The design of oligopeptide building blocks with dual enzymatic responsiveness allows us to create polymer networks that are formed and functionalized vi ...

2007

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