The Bristol stool scale is a diagnostic medical tool designed to classify the form of human faeces into seven categories. It is used in both clinical and experimental fields.
It was developed at the Bristol Royal Infirmary as a clinical assessment tool in 1997, and is widely used as a research tool to evaluate the effectiveness of treatments for various diseases of the bowel, as well as a clinical communication aid; including being part of the diagnostic triad for irritable bowel syndrome.
The seven types of stool are:
Type 1: Separate hard lumps, like nuts (difficult to pass)
Type 2: Sausage-shaped, but lumpy
Type 3: Like a sausage but with cracks on its surface
Type 4: Like a sausage or snake, smooth and soft (average stool)
Type 5: Soft blobs with clear cut edges
Type 6: Fluffy pieces with ragged edges, a mushy stool (diarrhea)
Type 7: Watery, no solid pieces, entirely liquid (diarrhea)
Types 1 and 2 indicate constipation, with 3 and 4 being the ideal stools as they are easy to defecate while not containing excess liquid, 5 indicating lack of dietary fiber, and 6 and 7 indicate diarrhoea.
In the initial study, in the population examined in this scale, the type 1 and 2 stools were more prevalent in females, while the type 5 and 6 stools were more prevalent in males; furthermore, 80% of subjects who reported rectal tenesmus (sensation of incomplete defecation) had type 7. These and other data have allowed the scale to be validated. The initial research did not include a pictorial chart with this being developed at a later point.
The Bristol stool scale is also very sensitive to changes in intestinal transit time caused by medications, such as antidiarrhoeal loperamide, senna, or anthraquinone with laxative effect.
Irritable bowel syndrome and Rome process
People with irritable bowel syndrome (IBS) typically report that they suffer with abdominal cramps and constipation.
In some patients, chronic constipation is interspersed with brief episodes of diarrhoea; while a minority of patients with IBS have only diarrhoea.
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The Rome process and Rome criteria are an international effort to create scientific data to help in the diagnosis and treatment of functional gastrointestinal disorders, such as irritable bowel syndrome, functional dyspepsia and rumination syndrome. The Rome diagnostic criteria are set forth by Rome Foundation, a not for profit 501(c)(3) organization based in Raleigh, North Carolina, United States. Several systematic approaches attempted to classify functional gastrointestinal disorders (FGIDs).
vignette|Matière fécale humaine. La matière fécale humaine ou les fèces humaines diffèrent grandement d'apparence, en fonction de l'état de l'ensemble de l'appareil digestif, qui subit lui-même l'influence du régime alimentaire et de la santé. Normalement, elles sont semi-solides et enrobées de mucus. De petits morceaux de selles plus dures, moins humides peuvent s'être incrustées dans l'extrémité distale (ce qui est normal lorsqu'un mouvement péristaltique du côlon est incomplet, et que des fèces retournent du rectum vers l'intestin, où l'eau est absorbée).
Le syndrome de l'intestin irritable (appelé également troubles fonctionnels intestinaux, ou colopathie fonctionnelle, ou encore syndrome du côlon irritable) est une maladie chronique à symptomatologie digestive en rapport avec des modifications de la motricité et de la sensibilité de l'intestin intriquées avec des facteurs psychologiques. Le diagnostic nécessite d'éliminer les pathologies à expression similaire les plus communes. Sans gravité, cette maladie fréquente retentit sur la qualité de vie.
Background Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bow ...
Since the first description of 5-HT3 receptors more than 50 years ago, there has been speculation about the molecular basis of their receptor heterogeneity. We have cloned the genes encoding novel 5-HT3 subunits 5-HT3C, 5-HT3D, and 5-HT3E and have shown th ...