The Arghun dynasty (Sindhi: ارغونن جي سلطنت) ruled over the area between Southern Afghanistan and Sindh from the late 15th century to the early 16th century. Arghun rule can be divided into two branches: the Arghun branch of Dhu'l-Nun Beg Arghun that ruled until 1554, and the Tarkhan branch of Muhammad 'Isa Tarkhan that ruled until 1591.
The ethnicity of the Arghuns has been described as Turkish, Turco-Mongol, and Mongol.
In the late 15th century, the Timurid sultan of Herat, Husayn Bayqarah, appointed Dhu'l-Nun Beg Arghun as governor of Kandahar. Dhu'l-Nun Beg soon began to ignore the authority of the central government in Herat and in around 1479 he began expanding in the direction of Baluchistan, taking over Pishin, Shal and Mastung. In 1485 his sons Shah Beg Arghun and Muhammad Mukim Khan also seized Sibi from the Samma dynasty of Sindh, although this gain was only temporary.
In 1497, Dhu'l-Nun Beg threw his support behind the revolt of Husayn Bayqarah's son Badi' al-Zaman against his father. Dhu'l-Nun Beg, who married off his daughter to Badi' al-Zaman, subsequently gained a prominent position in the latter's government when the Timurid succeeded Husayn Bayqarah in Herat in 1506. Unfortunately for them, the Uzbeks under Muhammad Shaybani invaded Khorasan shortly after Badi' al-Zaman's ascension. In 1507 Dhu'l-Nun Beg was killed in battle against the Uzbeks and succeeded by his sons Shah Beg and Mukim.
The Arghuns ultimately lost control of their portion of Afghanistan to the Timurid prince Babur, who had been expelled from Transoxiana by the Uzbeks and had made his way south to Husayn Bayqarah's kingdom. In 1501/1502 Mukim had peacefully gained the submission of Kabul, which was in chaos after the death of its ruler Ulugh Beg II. This was contested by Babur, who besieged and took the city in 1504; Mukim fell back to Kandahar.
After Dhu'l-Nun Beg's death Babur decided that as long as Shah Beg and Mukim remained in Kandahar they would remain a threat to them.