Concept

Biologie médicale

Publications associées (33)

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Hilal Lashuel, Lara Petricca, Anass Chiki, Sean Michael Deguire

Posttranslational modifications can have profound effects on the biological and biophysical properties of proteins associated with misfolding and aggregation. However, their detection and quantification in clinical samples and an understanding of the mecha ...

2017

Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease

Theo Lasser, Tristan Bolmont, Taoufiq Harach, Fabien Louis Claude Robert Jammes, Nicolas Jean Marc Antoine Duthilleul, Valentin Laurent Herbert Zufferey

The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSCs) and factors (stem cell factors) on cerebral amyloid beta (Aβ) pathology was investigated in a mouse model of Alzheimer's disease (AD). To this end, hMSCs were administered intraveno ...

Elsevier2017

Microfluidic staining technology and automated image processing for fast and accurate tissue-based diagnostics

Diego Gabriel Dupouy

The development of microfluidics has led to significant improvements in many areas of in vitro diagnostics. This thesis proposes the use of microfluidic device technology in the field of anatomic pathology, leading to faster and more accurate tissue-based ...

EPFL2016

Extra short incubation microfluidic assisted – fluorescence in situ hybridization (ESIMA-FISH)

Martinus Gijs, Raphaël Etienne Jean Trouillon, Huu Tuan Nguyen, Estelle Annick Cuttaz, Laurène Nathalie Dupont

Fluorescence in situ hybridization (FISH) is a powerful technique for evaluating the HER2 gene status in breast cancer specimen (1). However, most of FISH assays currently used in clinical laboratories are expensive and require long experimental time, up t ...

2016

Explaining the length threshold of polyglutamine aggregation

Paolo De Los Rios, Marc Hafner

The existence of a length threshold, of about 35 residues, above which polyglutamine repeats can give rise to aggregation and to pathologies, is one of the hallmarks of polyglutamine neurodegenerative diseases such as Huntington's disease. The reason why s ...

2012

Convex Formulation of Region-based Image Registration

Shima Sepehri

Medical Imaging is a necessary component of many applications, such as clinical diagnosis, event tracking and decision making. Segmentation of anatomical organs in a medical image is a helpful processing of medical images for clinical purposes. Accurate ma ...

2011

Application of broad-spectrum resequencing microarray for genotyping rhabdoviruses

Stewart Cole, Iain Old

The rapid and accurate identification of pathogens is critical in the control of infectious disease. To this end, we analyzed the capacity for viral detection and identification of a newly described high-density resequencing microarray (RMA), termed Pathog ...

2010

Dynamic calibration of our sense of time

Fosco Bernasconi

An accurate sense of time contributes to functions ranging from the perception and anticipation of sensory events to the production of coordinated movements. However, accumulating evidence demonstrates that time perception is subject to strong illusory dis ...

2010

Experimental Characterization of Pressure Wave Generation and Propagation in Biological Tissues

Kossi Agbeviade, Jacques Giovanola, Mathieu Benoit, Marcel Donnet

Aim of the study: This work develops a measurement technique for pressure waves in soft tissues. It aims at characterizing, understanding and modeling the generation and propagation of pressure waves in soft tissues, with a view towards medical application ...

Springer, 233 Spring Street, New York, Ny 10013, United States2009

Oxidative stress on biomaterials

Reactive Oxygen Species (ROS) is a family of oxygen-based active molecules, which are deeply involved in numerous crucial processes of cellular metabolism, where the redox equilibrium is very important. An imbalance between ROS and the cell ability to neut ...

EPFL2006

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