Concept

Potentialisation à long terme

Publications associées (355)

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi, Paolo Carloni

Author summary Adenylyl cyclases (ACs) are enzymes that can translate extracellular signals into the intracellular molecule cAMP, which is thus a 2nd messenger of extracellular events. The brain expresses nine membrane-bound AC variants, and AC5 is the dom ...

PUBLIC LIBRARY SCIENCE2019

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

Maria del Carmen Sandi Perez, Simone Astori, Eleni Vasilaki, Damien Sébastien Huzard

The stress response facilitates survival through adaptation and is intimately related to cognitive processes. The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been sugges ...

2019

The effect of frontoparietal paired associative stimulation on decision-making and working memory

Traian Popa

Previous single-site neurostimulation experiments have unsuccessfully attempted to shift decision-making away from habitual control, a fast, inflexible cognitive strategy, towards goal-directed control, a flexible, though computationally expensive strategy ...

ELSEVIER MASSON, CORPORATION OFFICE2019

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term ...

2019

Monitoring of the UHPFRC strengthened Chillon viaduct under environmental and operational variability

Constructed in 1969, the Chillon viaducts constitute a vital component of the Swiss roadway network. The bridge deck was strengthened in 2015 by means of an Ultra High Performance Fiber Reinforced Cement-based Composite for alleviating the effects of deter ...

2019

Assessing the compressive strength of concrete under sustained actions: From refined models to simple design expressions

Aurelio Muttoni, Miguel Fernández Ruiz, Darko Tasevski

The detrimental influence of high levels of sustained load on the compressive strength of concrete has been acknowledged and investigated since the 1950s. Despite the potential significance of this phenomenon in many situations, current design codes still ...

2019

Strengthening of a 19th-century roadway metallic bridge using nonprestressed bonded and prestressed unbonded CFRP plates

Ardalan Hosseini, Masoud Motavalli, Elyas Ghafoori

This paper summarizes the strengthening of a historically significant 122-year-old roadway metallic bridge using nonprestressed bonded carbon fiber reinforced polymer (CFRP) plates. Prior to the bridge strengthening, sets of laboratory tests were conducted ...

2019

Temporal Spiking Recurrent Neural Network for Action Recognition

Wei Wang, Siyuan Hao

In this paper, we propose a novel temporal spiking recurrent neural network (TSRNN) to perform robust action recognition in videos. The proposed TSRNN employs a novel spiking architecture which utilizes the local discriminative features from high-confidenc ...

2019

Computational design of G Protein-Coupled Receptor allosteric signal transductions

Patrick Daniel Barth, Dániel Kéri

Membrane receptors sense and transduce extracellular stimuli into intracellular signaling responses but the molecular underpinnings remain poorly understood. We report a computational approach for designing protein allosteric signaling functions. By combin ...

2019

Electrical integration of two 1MW/2s dual-frequency gyrotrons into the EC-system of the TCV tokamak

Stefano Alberti, Damien Fasel, Ugo Siravo, Jérémie Dubray, Albert Perez

The electron-cyclotron heating system of the TCV tokamak is being enhanced as part of a major upgrade. Two MW-class dual-frequency gyrotrons will be installed. The first has already been delivered and will be fully commissioned on-site by the end of 2018 w ...

ELSEVIER SCIENCE SA2019

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search