Concept

Lame (microscopie)

Publications associées (32)

High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer

Martinus Gijs, Daniel Migliozzi, Huu Tuan Nguyen

Immunohistochemistry and fluorescence in situ hybridization are the two standard methods for human epidermal growth factor receptor 2 (HER2) assessment. However, they have severe limitations to assess quantitatively intratumoral heterogeneity (ITH) when mu ...

NATURE PUBLISHING GROUP2019

Improved Alkali Intercalation of Carbonaceous Materials in Ammonia Solution

László Forró, Bálint Náfrádi, Péter Szirmai, Ferenc Simon, Bence Gábor Márkus, Sándor Kollarics

Alkali-intercalated graphite compounds represent a compelling modification of carbon with significant application potential and various fundamentally important phases. The intercalation of graphite with alkali atoms (Li and K) using liquid ammonia solution ...

WILEY-V C H VERLAG GMBH2019

Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections

Martinus Gijs, Daniel Migliozzi, Diego Gabriel Dupouy, Benjamin Pelz

Because of the close interaction between tumors and the immune system, immunotherapies are nowadays considered as the most promising treatment against cancer. In order to define the diagnosis and the subsequent therapy, crucial information about the immune ...

2019

Compact lensless digital holography

Manon Rostykus

Microscopy is of high interest for biology since it allows imaging features that are too small to be seen with naked eyes. However, cells are mostly transparent to visible and infrared light which makes it difficult to see with a traditional microscope. To ...

EPFL2018

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Olivier Burri, Jeffrey Alan Hubbell, Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Miriella Carmela Pasquier, Edward Allen Phelps, Andreas Wiederkehr, Gabriele Galliverti

A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and livecell microscopy. Guided by an observation that dispersed isle ...

Springer Nature2017

Microfluidic and Electrokinetic Manipulation of Single Cells

Samuel Kilchenmann

Traditional cell assays report on the average results of a cell population. However, a wide range of new tools are being developed for a fundamental understanding of single cell's functionality. Nonetheless, the current tools are either limited in their th ...

EPFL2017

Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography

Henning Paul-Julius Stahlberg

High-throughput three-dimensional cryogenic imaging of thick biological specimens is valuable for identifying biologically-or pathologically-relevant features of interest, especially for subsequent correlative studies. Unfortunately, high-resolution imagin ...

Springer Nature2017

Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping

Romuald Houdré, Nicolas Maxime André Descharmes, Mario Lucien Henri Tonin

We demonstrate the fabrication of a hybrid PDMS/glass microfluidic layer that can be placed on top of non-transparent samples and allows high-resolution optical microscopy through it. The layer mimics a glass coverslip to limit optical aberrations and can ...

Royal Society of Chemistry2016

Studies on large scale bridging in delamination of unidirectional and cross-ply laminates

Ebrahim Farmand Ashtiani

Delamination propagation in fibrous laminates is often accompanied by development of a damage zone, within which intact fibers bridge the crack faces that constitutes a major toughening mechanism. A direct experimental assessment of the crack closure tract ...

EPFL2016

Extra short incubation microfluidic assisted – fluorescence in situ hybridization (ESIMA-FISH)

Martinus Gijs, Raphaël Etienne Jean Trouillon, Huu Tuan Nguyen, Estelle Annick Cuttaz, Laurène Nathalie Dupont

Fluorescence in situ hybridization (FISH) is a powerful technique for evaluating the HER2 gene status in breast cancer specimen (1). However, most of FISH assays currently used in clinical laboratories are expensive and require long experimental time, up t ...

2016

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