Concept
Interleukine 23
Publications associées (32)
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia
Constitutive activation of STAT5 is critical for the maintenance of chronic myeloid leukemia (CML) characterized by the BCR-ABL oncoprotein. Tyrosine kinase inhibitors (TKIs) for the STAT5-activating kinase JAK2 have been discussed as a treatment option fo ...
Nature Publishing Group2012Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses
B-cell-activating factor of the TNF family (BAFF)/BLyS contributes to B-cell homeostasis and function in the periphery. BAFF is expressed as a membrane-bound protein or released by proteolytic cleavage, but the functional importance of this processing even ...
Wiley-Blackwell2011Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin
Freddy Radtke, Ute Koch, Matteo Di Piazza
BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...
Public Library of Science2010Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function
Nicola Harris, Benjamin John Marsland
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, mainly expressed by epithelial cells, and key to the development of allergic responses. The well-documented involvement of TSLP in allergy has led to the conviction that TSLP promo ...
2009Thymic epithelial cells
As primary lymphoid organ, the thymus provides the essential environment for maturation and selection of functional T lymphocytes. Thymic epithelial (TE) cells derive from the endoderm, and more specifically, from the third pharyngeal pouch. The thymic epi ...
EPFL2008T cell-independent, TLR-induced IL-12p70 production in primary human monocytes
IL-12p70 is a key cytokine for the induction of Th1 immune responses. IL-12p70 production in myeloid cells is thought to be strictly controlled by T cell help. In this work we demonstrate that primary human monocytes can produce IL-12p70 in the absence of ...
American Association of Immunologists2006The role of B7 costimulation in T-cell immunity
CD4(+) T cells are considered to be the major controlling element of the adaptive immune response. They recognize foreign peptides by interaction of the T cell receptor (TCR) with peptide complexed to major histocompatibility complex (MHC) class II molecul ...
1999The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon
The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the ...
1995