Concept

Débat inné et acquis

Publications associées (32)

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

Jacques Fellay, Amalio Telenti, Istvan Bartha

Previous genome-wide association studies (GWAS) of HIV-1-infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. ...

Natl Acad Sciences2015

When Others Impinge upon Your Privacy

Mathias Jacques Jean-Marc Humbert

Privacy is defined as the right to control, edit, manage, and delete information about oneself and decide when, how, and to what extent this information is communicated to others. Therefore, every person should ideally be empowered to manage and protect hi ...

EPFL2015

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Philippe Renaud, John McKinney, Neeraj Dhar, Rodrigo Martinez Duarte, Meltem Elitas

Persistence of bacteria during antibiotic therapy is a widespread phenomenon, of particular importance in refractory mycobacterial infections such as leprosy and tuberculosis. Persistence is characterized by the phenotypic tolerance of a subpopulation of b ...

Royal Soc Chemistry2014

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

Evan Graehl Williams

For more than a century, it has been recognized that our genetic inheritance and our environment interact to shape who we are and how we act (nature vs. nurture), and the study of genetics has allowed us to explain why traits can vary dramatically betwee ...

EPFL2014

Models of Reward-Modulated Spike-Timing-Dependent Plasticity

Nicolas Frémaux

How do animals learn to repeat behaviors that lead to the obtention of food or other “rewarding” objects? As a biologically plausible paradigm for learning in spiking neural networks, spike-timing dependent plasticity (STDP) has been shown to perform well ...

EPFL2013

Accelerating the calculation of time-resolved electronic spectra with the cellular dephasing representation

Jiri Vanicek, Miroslav Sulc

Dephasing representation of fidelity, also known as the phase averaging method, can be considered as a special case of Miller's linearized semiclassical initial value representation and belongs among the most efficient approximate semiclassical approaches ...

Taylor & Francis2012

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Nouchine Hadjikhani, Fei Chen

Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution(1). Recent extensive genome-wide association studies (GWASs) have identified numerous si ...

2010

Transcriptional regulation of lipid homeostasis in mycobacteria

Stewart Cole, Claudia Sala

Mycolic acids are major components of the cell envelope of mycobacteria, such as Mycobacterium tuberculosis, and play an important role in its architecture, impermeability and interaction with the environment. Synthesis of mycolic acids is carried out by t ...

2010

Histone methyl transferases and demethylases; can they link metabolism and transcription?

Johan Auwerx, Kristina Schoonjans

Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine resi ...

Elsevier2010

Reliable confidence intervals in quantitative genetics: Narrow-sense heritability

Anthony Christopher Davison

Many quantitative genetic statistics are functions of variance components, for which a large number of replicates is needed for precise estimates and reliable measures of uncertainty, on which sound interpretation depends. Moreover, in large experiments th ...

2007

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