Concept

Fitness function

Publications associées (84)

Sampling can be faster than optimization

Optimization algorithms and Monte Carlo sampling algorithms have provided the computational foundations for the rapid growth in applications of statistical machine learning in recent years. There is, however, limited theoretical understanding of the relati ...

PNAS2019

Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes

Freddy Radtke

Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem. Therapeutic options are restricted due to a poor understanding of the pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, prolifera ...

2019

Structurally informed exploration of a grammar-based design space

Graphic statics provide a visual understanding of the relation between a structures’ shape and its efforts, a valuable quality in the field of structural conception. When combined to a shape grammar, the graphical method has proven to be a very powerful to ...

2018

The fitness landscape of the codon space across environments

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

Fitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role of synonymous mutations. To quantify the fitnes ...

NATURE PUBLISHING GROUP2018

Interactive optimization for supporting multicriteria decisions in urban and energy system planning

Sébastien Cajot

Climate change and growing urban populations are increasingly putting pressure on cities to reduce their carbon emissions and transition towards efficient and renewable energy systems. This challenges in particular urban planners, who are expected to integ ...

EPFL2018

Single Neuron Optimization as a Basis for Accurate Biophysical Modeling : The Case of Cerebellar Granule Cells

Werner Alfons Hilda Van Geit, Stefano Masoli, Egidio D'Angelo

In realistic neuronal modeling, once the ionic channel complement has been defined, the maximum ionic conductance (Gi-max) values need to be tuned in order to match the firing pattern revealed by electrophysiological recordings. Recently, selection/mutatio ...

Frontiers Media Sa2017

Modeling and Designing of a Radial Anode Off-Gas Recirculation Fan for Solid Oxide Fuel Cell Systems

Jan Van Herle, Jürg Alexander Schiffmann, Stefan Diethelm, Zacharie Wuillemin, Patrick Hubert Wagner

To improve the industry benchmark of solid oxide fuel cell (SOFC) systems, we consider anode off-gas recirculation (AOR) using a small-scale fan. Evolutionary algorithms compare different system design alternatives with hot or cold recirculation. The syste ...

2017

Radio Resource Management Optimization of Flexible Satellite Payloads for DVB-S2 Systems

Giuseppe Cocco

The increasing demand for high-rate broadcast and multicast services over satellite networks has pushed for the development of high throughput satellites characterized by a large number of beams (e.g., more than 100). This, together with the variable distr ...

2017

The Seamless Peer and Cloud Evolution Framework

Dario Floreano, Joshua Evan Auerbach, Giovanni Iacca, Guillaume Paul Olivier Leclerc

Evolutionary algorithms are increasingly being applied to problems that are too computationally expensive to run on a single personal computer due to costly fitness function evaluations and/or large numbers of fitness evaluations. Here, we introduce the Se ...

ACM Press2016

On the (un) predictability of a large intragenic fitness landscape

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving ever-increasing attention. Novel experimental approaches combined with next-generation sequencing (NGS) methods enable accurate and extensive studies of the fitness e ...

Natl Acad Sciences2016

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