Publications associées à Folding@home

Hydrocarbon adsorption in an aqueous environment: A computational study of alkyls on Cu(111)

Hydrocarbon chains are important intermediates in various aqueous-phase surface processes, such as CO2 electroreduction, aqueous Fischer-Tropsch synthesis, and aqueous phase reforming of biomass-derived molecules. Further, the interaction between water and ...

American Institute of Physics2016

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

Pierre Goloubinoff, Andrija Finka

Molecular chaperones control the cellular folding, assembly, unfolding, disassembly, translocation, activation, inactivation, disaggregation, and degradation of proteins. In 1989, groundbreaking experiments demonstrated that a purified chaperone can bind a ...

Annual Reviews2016

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

Horst Vogel, Shuguang Yuan

G-protein-coupled receptors (GPCRs) are involved in a wide range of physiological processes, and they have attracted considerable attention as important targets for developing new medicines. A central and largely unresolved question in drug discovery, whic ...

Wiley-Blackwell2016

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

Paul Guichard, Virginie Hamel

Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardtii SAS- ...

Nature Publishing Group2016

Protein-protein structure prediction by scoring molecular dynamics trajectories of putative poses

Bruno Emanuel Ferreira De Sousa Correia, Stefano Zamuner

The prediction of protein-protein interactions and their structural configuration remains a largely unsolved problem. Most of the algorithms aimed at finding the native conformation of a protein complex starting from the structure of its monomers are based ...

Wiley-Blackwell2016

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides

Hilal Lashuel, Loay Awad, Ritwik Burai, Nino Jejelava

We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can ...

Wiley-Blackwell2016

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Michal Feldman Elmalam, Elsa Anne Perrody

Many membrane proteins fold inefficiently and require the help of enzymes and chaperones. Here we reveal a novel folding assistance system that operates on membrane proteins from the cytosolic side of the endoplasmic reticulum (ER). We show that folding of ...

Elife Sciences Publications Ltd2016

Timber Folded Plate Structures – Folded Form Analysis

Yves Weinand, Christopher Werner Matthias Robeller, Andrea Stitic

This paper analyses the potential of different possible folded form topologies for generating timber folded surface structures. The main advantage of such structures lies primarily in the realm of ecology and sustainability. By offering an integral way of ...

2015

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Folding@home

Hydrocarbon adsorption in an aqueous environment: A computational study of alkyls on Cu(111)

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

An advection-diffusion model for cross-field runaway electron transport in perturbed magnetic fields

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

Protein-protein structure prediction by scoring molecular dynamics trajectories of putative poses

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

Five Questions (with their Answers) on ER-Associated Degradation

Timber Folded Plate Structures – Folded Form Analysis

Graph Chatbot

Chattez avec Graph Search

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

Hydrocarbon adsorption in an aqueous environment: A computational study of alkyls on Cu(111)

An advection-diffusion model for cross-field runaway electron transport in perturbed magnetic fields

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides

Five Questions (with their Answers) on ER-Associated Degradation

Protein-protein structure prediction by scoring molecular dynamics trajectories of putative poses

Timber Folded Plate Structures – Folded Form Analysis

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6