Concept

Sequence motif

Publications associées (92)

Accurate whole human genome sequencing using reversible terminator chemistry

Gerardo Turcatti, Ho Ling Li, Lu Zhang, Anil Kumar, Jingwen Wang

DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400-800 base pair) reads, but the existence of reference sequences for the human and man ...

2008

Clustering protein environments for function prediction: finding PROSITE motifs in 3D

Giovanni De Micheli

Background: Structural genomics initiatives are producing increasing numbers of three-dimensional (3D) structures for which there is little functional information. Structure-based annotation of molecular function is therefore becoming critical. We previous ...

BioMed Central2007

Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells

Philipp Bucher, Stefania Puttini

Gene transfer in eukaryotic cells and organisms suffers from epigenetic effects that result in low or unstable transgene expression and high clonal variability. Use of epigenetic regulators such as matrix attachment regions (MARs) is a promising approach t ...

2007

Human telomerase RNA accumulation in cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

Joachim Lingner, Katarzyna Sikora

Telomerase is required for telomere maintenance and is responsible for the immortal phenotype of cancer cells. How telomerase is assembled and reaches telomeres in the context of nuclear architecture is not understood. Recently, the telomerase RNA subunit ...

2007

One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition

Jieping Zhu

By combining three appropriately designed simple substrates, a programmed sequence involving an alpha -isocyano acetamide-based three-component reaction followed by a copper-catalyzed intramol. [3+2] cycloaddn. of alkyne and azide took place to afford comp ...

2006

Similarities and differences of polyadenylation signals in human and fly

Felix Naef, Philipp Bucher

ABSTRACT: BACKGROUND: Cleavage of messenger RNA (mRNA) precursors is an essential step in mRNA maturation. The signal recognized by the cleavage enzyme complex has been characterized as an A rich region upstream of the cleavage site containing a motif with ...

2006

Exploring Contextual Information in a Layered Framework for Group Action Recognition

Daniel Gatica-Perez, Samy Bengio, Dong Zhang

Contextual information is important for sequence modeling. Hidden Markov Models (HMMs) and extensions, which have been widely used for sequence modeling, make simplifying, often unrealistic assumptions on the conditional independence of observations given ...

2006

Exploring Contextual Information in a Layered Framework for Group Action Recognition

Daniel Gatica-Perez, Samy Bengio, Dong Zhang

IDIAP2006

InterPro, progress and status in 2005

Philipp Bucher, Amos Bairoch

InterPro, an integrated documentation resource of protein families, domains and functional sites, was created to integrate the major protein signature databases. Currently, it includes PROSITE, Pfam, PRINTS, ProDom, SMART, TIGRFAMs, PIRSF and SUPERFAMILY. ...

2005

Signal search analysis server

Giovanna Ambrosini, Philipp Bucher

Signal search analysis is a general method to discover and characterize sequence motifs that are positionally correlated with a functional site (e.g. a transcription or translation start site). The method has played an instrumental role in the analysis of ...

2003

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