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Being able to efficiently segment a developing embryo from background clutter constitutes an important step in automated monitoring of human embryonic cells. State-of-the-art automatic segmentation methods remain ill-suited to handle the complex behavior a ...
The ligand-dependent nuclear receptors PPARgamma and RXRalpha/beta were recently determined to be essential for murine placental development and trophoblast differentiation. In the current study we examined the expression and role of the PPARgamma/RXRalpha ...
Recent studies performed with null mice suggested a role of either RXR alpha or PPAR gamma in murine placental development. We report here that both PPAR gamma and RXR alpha are strongly expressed in human villous cytotrophoblasts and syncytiotrophoblasts. ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%). Although the mice are physically normal and the inductio ...
Introduction. Development of the fetal brain surface with concomitant gyrification is one of the major maturational processes of the human brain. First delineated by postmortem studies or by ultrasound, MRI has recently become a powerful tool for studying ...
Signaling cascades that control adipogenesis are essential in the regulation of body weight and obesity. The adaptor p62 controls pathways that modulate cell differentiation. We report here that p62(-/-) mice develop mature-onset obesity, leptin resistance ...
