Concept
Gliose
Publications associées (94)
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments
Graham Knott, Corrado Cali, Nicole Déglon, Tamara Zehnder, Luca Pucci, Andrea Chicca
Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities and cognitive deficits commonly observed in psychiatric dis ...
2020Lactate enhancing compounds and uses thereof
Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald
Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...
2020Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease
Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic plasticity and behavioral deficits in AD is not known. Here, we show that th ...
CELL PRESS2020Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity
Tobias Kober, Bénédicte Marie Maréchal, Mario Joao Fartaria de Oliveira
Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease prog ...
2020Optical phase contrast imaging of human retinal cells by changing the tissue refractive index
Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Mathieu Künzi
Purpose : Based on oblique partially coherent illumination of transparent samples, we developed a simple custom Optical Phase Imaging (OPI) microscope providing a label-free, semi-quantitative phase contrast imaging. The aim of this study was to explore th ...
ASSOC RESEARCH VISION OPHTHALMOLOGY INC2020Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
Bernard Schneider, Philippe Colin, Vanessa Laversenne
The brain pathology of Alzheimer’s disease (AD) is characterized by the misfolding and aggregation of both the amyloid beta (Aβ) peptide and hyperphosphorylated forms of the tau protein. Initial Aβ deposition is considered to trigger a sequence of deleteri ...
2020Extra-axonal restricted diffusion as an in-vivo marker of reactive microglia
Anne des Rieux, Gaëtan Olivier D Rensonnet, Benoît Macq
Reactive microgliosis is an important pathological component of neuroinflammation and has been implicated in a wide range of brain diseases including brain tumors, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and schizophrenia. Mapping rea ...
2019Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy
Cristina Ramona Cudalbu, Jocelin Grosse, Katarzyna Pierzchala, Veronika Rackayová
Background & Aims: The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal change ...
2019Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly. AD is characterized by the deposition of two aggregated proteins: Amyloid beta (Aß) and hyperphosphorylated tau. Accumulations of these proteins are thought to be the signature ...
EPFL2019Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen
Elise Marie Catherine Vinckenbosch
Magnetic resonance at ultra-high field increases signal and spectral dispersion. In this thesis, I use those characteristics to investigate three different subjects in 13C spectroscopy, hyperpolarized methods and chemical exchange saturation transfer (CEST ...
EPFL2018