Publications associées à Self-replicating spacecraft

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

One of the goals of synthetic biology is the development of an artificial cell. Building an artificial cell from scratch will provide a deeper understanding of fundamental mechanisms and models in biology and promises to contribute towards building novel p ...

EPFL2024

Planetary-Scale Byzantine Fault Tolerance

Matteo Monti

The scale and pervasiveness of the Internet make it a pillar of planetary communication, industry and economy, as well as a fundamental medium for public discourse and democratic engagement. In stark contrast with the Internet's decentralized infrastructur ...

EPFL2024

uBFT: Microsecond-Scale BFT using Disaggregated Memory

Rachid Guerraoui, Antoine Murat, Mihail Igor Zablotchi, Athanasios Xygkis, Naama Ben David

We propose uBFT, the first State Machine Replication (SMR) system to achieve microsecond-scale latency in data centers, while using only 2f+1 replicas to tolerate f Byzantine failures. The Byzantine Fault Tolerance (BFT) provided by uBFT is essential as pu ...

2023

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

Barbora Lavickova

Thanks to recent advancements in synthetic biology, the dream of creating a synthetic cell has become feasible. However, due to its inherent complexity, one of the fundamental functions of all living systems, i.e., self-replication, remains to be introduce ...

EPFL2021

Replicated state machines without replicated execution

Kirill Nikitin

This paper introduces a new approach to reduce end-to-end costs in large-scale replicated systems built under a Byzantine fault model. Specifically, our approach transforms a given replicated state machine (RSM) to another RSM where nodes incur lower costs ...

IEEE2020

System Support for Efficient Replication in Distributed Systems

Dragos-Adrian Seredinschi

Current online applications, such as search engines, social networks, or file sharing services, execute across a distributed network of machines. They provide non-stop services to their users despite failures in the underlying network. To achieve such a hi ...

EPFL2019

Nanostructured surface topographies have an effect on bactericidal activity

Jürgen Brugger, Songmei Wu

Background Due to the increased emergence of antimicrobial resistance, alternatives to minimize the usage of antibiotics become attractive solutions. Biophysical manipulation of material surface topography to prevent bacterial adhesion is one promising app ...

2018

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri

During their lifespan, Red blood cells (RBC), due to their inability to self-replicate, undergo an ageing degradation phenomenon. This pathway, both in vitro and in vivo, consists of a series of chemical and morphological modifications, which include devia ...

2018

Mask-aligner Talbot lithography using a 193 nm CW light source

Toralf Scharf, Wilfried Noell, Raoul Kirner, Andreas Vetter

We present and discuss Talbot mask-aligner lithography, relying on a continuous wave laser emitting at 193nm for the illumination. In this source, a diode laser at 772nm is amplified by a tapered amplifier in master-oscillator power-amplifier configuration ...

2018

On the Limits of Precision Glass Molding for Diffractive Optical Elements

Karin Prater

Diffractive optical elements (DOEs) consist of surface reliefs with dimensions in the micrometer range and nanometer precision. Two technologies dominate: Elements replicated in plastic and directly microfabricated elements in fused silica. Plastic DOEs ar ...

EPFL2017