Concept

Addition nucléophile

Publications associées (133)

SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels

Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing protease-sensitive peptide crosslinkers have previously been described as matrices for cell-induced enzymatic r ...

2011

Benefits of a Tangible Interface for Collaborative Learning and Interaction

Pierre Dillenbourg, Patrick Jermann, Guillaume Zufferey, Bertrand Roland Schneider

We investigated the role that tangibility plays in a problem-solving task by observing logistic apprentices using either a multitouch or a tangible interface. Results showed that tangibility helped them perform the task better and achieve a higher learning ...

2011

Heteroatom-Nucleophile-Induced C-C Fragmentations: Synthesis of Allenes and Entry to Domino Reactions

Nicolai Cramer, Tanguy Jean Daniel Saget

Heteroatom nucleophiles (NuH) induce Grob-type fragmentations of cyclic vinyl triflates under mild conditions and provide œâ-allene-functionalized carboxylic acid derivs. These products are a versatile starting point for domino and one-pot reactions access ...

Wiley-VCH Verlag GmbH & Co. KGaA2010

Synthesis of Unusual Oxime Ethers by Reaction of Tetranitromethane with B-Alkylcatecholboranes

Philippe Renaud, Kurt Schenk

The reaction of tetranitromethane with B-alkylcatecholboranes leads to the formation of unusual dinitrooxime ethers. A tentative mechanism is provided, which suggests the involvement of extremely fast addition of alkyl radicals to tetranitromethane. The su ...

2010

Nucleophilic Substitutions of Nitroarenes and Pyridines: New Insight and New Applications

At the beginning of this article an in-depth comparison of electrophilic and nucleophilic aromatic and heterocyclic substitution processes examines their scopes of applicability in a new light. In the subsequent parts, recent progress in the area of halide ...

2010

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases

Pierre Vogel, Inmaculada Robina, Claudia Bello, Yolanda Vera-Ayoso

The stereoselective synthesis of new 3,4-dihydroxypyrrolidine derivatives starting from D-mannose, D-ribose and L-fucose is presented. Two synthetic strategies employing organometallic addition to hemiacetalic sugars followed by selective nucleophilic disp ...

2009

Chiral Bronsted Acid-Catalyzed Enantioselective Multicomponent Mannich Reaction: Synthesis of anti-1,3-Diamines Using Enecarbamates as Nucleophiles

Jieping Zhu

Reaction of aldehydes, anilines, and enecarbamates in dichloromethane in the presence of EtOH and a catalytic amt. of chiral phosphoric acid I afforded the Mannich adducts which were in situ reduced to anti-1,2-disubstituted 1,3-diamines II in excellent di ...

2009

Site Selective Functionalization of Fluorinated Nitrogen Heterocycles

Alain Borel, Luc Patiny

Functional groups are prerequisites for the assembly of building blocks to more elaborate structures for research work in the life sciences field. Functionalization can be most conveniently and efficaciously accomplished by generating an organometallic der ...

American Chemical Society2009

Retrieving photochemically active structures by time-resolved EXAFS spectroscopy

Majed Chergui, Wojciech Gawelda, Camelia Borca, Van Thai Pham, Amal El Nahhas, Renske Marjan van der Veen, Frederico Alves Lima

Describing the nature and structure of molecular excited states is important in order to understand their chemical reactivity and role as intermediates in photochemical reactions. The recent implementation of x-ray absorption spectroscopy in the ultrafast ...

Iop Publishing Ltd, Dirac House, Temple Back, Bristol Bs1 6Be, England2009

Gas-assisted focused electron beam and ion beam processing and fabrication

Patrik Willi Hoffmann, Ivo Utke

Beams of electrons and ions are now fairly routinely focused to dimensions in the nanometer range. Since the beams can be used to locally alter material at the point where they are incident on a surface, they represent direct nanofabrication tools. The aut ...

2008

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