Concept
Mirtazapine
Publications associées (12)
Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions
Alessandro Angelini, Alessandro Zorzi, Sara Linciano
Human serum albumin (hSA) is the major carrier protein for fatty acids (FAs) in plasma. Its ability to bind multiple FA moieties with moderate to high affinity has inspired the use of FA conjugation as a safe and natural platform to generate long-lasting t ...
ELSEVIER2022Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes
Nako Nakatsuka, Dmitry Momotenko
The serotonergic system in the human brain modulates several physiological processes, and altered serotonergic neurotransmission has been implicated in the neuropathology of several psychiatric disorders. The study of serotonergic neurotransmission in psyc ...
2021Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression
Pierre Magistretti, Jean-René Cardinaux
Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...
Nature Publishing Group2016Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Hilal Lashuel, Patrick Fraering, Saviana Di Giovanni, Simona Eleuteri
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this p ...
2015A Biochemical and Biophysical Investigation of 5-HT3 Receptor Stability
The 5-hydroxytryptamine 3 receptor (5-HT3R) is a member of the pentameric ligand-gated ion channel (pLGIC) family, that plays an important role in fast signal transduction and cell-cell communication in synapses: They convert a chemical signal from a neuro ...
EPFL2012