Concept

Cortico-basal ganglia-thalamo-cortical loop

Publications associées (125)

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Friedhelm Christoph Hummel, Takuya Morishita, Pierre Theopistos Vassiliadis, Elena Beanato, Esra Neufeld, Fabienne Windel, Maximilian Jonas Wessel, Traian Popa, Julie Duqué

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Nature Portfolio2024

Subcortical correlates of consciousness with human single neuron recordings

Olaf Blanke, Fosco Bernasconi, Nathan Quentin Faivre, Michael Eric Anthony Pereira

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

2024

Striatal Dopamine Signals and Reward Learning

Carl Petersen, Sylvain Crochet, Yanqi Liu, Parviz Ghaderi, Mauro Pulin, Anthony Pierre Robert Renard, Christos Sourmpis, Pol Bech Vilaseca, Meriam Malekzadeh, Robin François Virginien Dard

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Oxford2023

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Matthias Wolf, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Werner Alfons Hilda Van Geit, James Gonzalo King, Pramod Shivaji Kumbhar, Alexis Arnaudon, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Armando Romani, András Ecker, Michael Emiel Gevaert, Vishal Sood, Sirio Bolaños Puchet, James Bryden Isbister, Judit Planas Carbonell, Daniela Egas Santander, Maria Reva, Genrich Ivaska, Natali Barros Zulaica, Mustafa Anil Tuncel, Christoph Pokorny, Elvis Boci, Jorge Blanco Alonso, Aleksandra Zuzanna Teska, Darshan Mandge, Polina Litvak, Gianluca Ficarelli, Weina Ji, Giuseppe Chindemi, Christian Andreas Rössert, Omar Awile, Joni Henrikki Herttuainen, Samuel Lieven D. Lapere, Thomas Brice Delemontex, Tanguy Pierre Louis Damart, Alexander Dietz

In recent years, large-scale computational models of the cortex have emerged as a powerful way to study the multi-scale mechanisms of neural processing. However, due to computational costs and difficulty of parameterization, detailed biophysical reconstruc ...

2023

Longitudinal evaluation of the mechanisms supporting post-stroke motor recovery using TMS-EEG coupling

Andéol Geoffroy Cadic-Melchior

Stroke is the main source of long-lasting disability, affecting dominantly motor functions. The extent and course of recovery are highly heterogeneous between patients, with a minority of patients fully recovering from their initial impairments, leaving 85 ...

EPFL2023

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Simon Borgognon

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

SOC NEUROSCIENCE2023

Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait

Silvestro Micera, Fiorenzo Artoni

The effects of robotic-assisted gait (RAG) training, besides conventional therapy, on neuroplasticity mechanisms and cortical integration in locomotion are still uncertain. To advance our knowledge on the matter, we determined the involvement of motor cort ...

Berlin2023

Engram cell connectivity as a mechanism for information encoding and memory function

Maurizio Ferdinando Pezzoli

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

Cambridge2023

A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions

Vignayanandam Ravindernath Muddapu

In order to understand the link between substantia nigra pars compacta (SNc) cell loss and Parkinson's disease (PD) symptoms, we developed a multiscale computational model that can replicate the symptoms at the behavioural level by incorporating the key ce ...

FRONTIERS MEDIA SA2022

Modeling and simulation of rat non-barrel somatosensory cortex. Part I: Modeling anatomy

Matthias Wolf, Henry Markram, Kathryn Hess Bellwald, Felix Schürmann, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Werner Alfons Hilda Van Geit, James Gonzalo King, Lida Kanari, Pramod Shivaji Kumbhar, Alexis Arnaudon, Ying Shi, Jean-Denis Georges Emile Courcol, Armando Romani, András Ecker, Michael Emiel Gevaert, Cyrille Pierre Henri Favreau, Vishal Sood, Sirio Bolaños Puchet, James Bryden Isbister, Judit Planas Carbonell, Daniela Egas Santander, Christoph Pokorny, Adrien Michel Achille Devresse, Gianluca Ficarelli, Hugo Thabo Dictus, Janis Lazovskis, Juan Bautista Hernando Vieites, Huanxiang Lu, Liesbeth Maria L Vanherpe, Ran Levi, Joni Henrikki Herttuainen, Samuel Lieven D. Lapere, Juan Luis Riquelme Roman, Thomas Brice Delemontex, Nicolas René Jean Ninin, Alexander Dietz, Benoît Jean-Albert Coste

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2022

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search