Publications associées à Chemical specificity

Deamidation and Transamidation of Substance P by Tissue Transglutaminase Revealed by Electron-Capture Dissociation Fourier Transform Mass Spectrometry (Chem. Eur. J. 2/2011)

Horst Vogel, Yury Tsybin, Luigino Grasso, Adrian Schmid, Luca Fornelli

Tissue transglutaminase (tTGase) catalyzes both deamidation and transamidation of peptides and proteins by using a peptidyl glutamine as primary substrate. A precise consensus sequence for the enzyme is unknown and the ratio between deamidated and transami ...

Wiley-Blackwell2011

Fetal Epiphyseal Chondrocytes Behavior within 3D Hydrogels

Philippe Abdel Sayed, Azadeh Khoushabi, Salim Elias Darwiche

Of the many external factors that affect cell behavior, mechanical cues have been found to be fundamental in modulating a cell’s phenotype. Indeed, merely changing substrate stiffness in monolayer culture systems generates drastically different phenotypes ...

2011

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

Jeffrey Alan Hubbell, Jennifer Patterson

Bioactive hydrogels formed by Michael-type addition reactions of end-functionalized poly(ethylene glycol) macromers with cysteine-containing peptides have been described as extracellular matrix mimetics and tissue engineering scaffolds. Although these mate ...

Elsevier2010

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

Stephane Kontos, Jeffrey Alan Hubbell

Poor pharmacokinetic profiles are often the underlying reason for the failure of novel protein drugs to reach clinical translation. Current passive half-life improvement methods focus on increasing the apparent hydrodynamic radius of the drug. We sought to ...

American Chemical Society2010

Two-Dimensional Polymer Formation on Surfaces: Insight into the Roles of Precursor Mobility and Reactivity

Daniele Passerone, Matthias Treier, Jinming Cai

We report on a combined scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS), and density functional theory (DFT) study on the surface-assisted assembly of the hexaiodosubstituted macrocycle cyclohexa-m-phenylene (CHP) toward covalen ...

American Chemical Society2010

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Jeffrey Alan Hubbell, Mikaël Martino

It has recently been shown that some growth factors (GFs) have strong interactions with nonproteoglycan extracellular matrix proteins. Relevant here, the 12th-14th type three repeats of fibronectin (FN III12-14) have been shown to bind insulin-like growth ...

Federation of American Society of Experimental Biology2010

Force spectroscopy of barnase-barstar single molecule interaction

Giovanni Dietler, Mélanie Favre, Dmitry Klinov

Results of the single molecule force spectroscopy study of specific interactions between ribonuclease barnase and its inhibitor barstar are presented. Experimental data obtained for the force loading rate ranging 2-70 nN/s are well approximated by a single ...

Wiley-Blackwell2010

Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry

Hubert Girault, Liang Qiao, Manuel Alejandro Méndez Agudelo, Mohamad Hojeij, Hongyan Bi

A specific multi-phosphopeptide enrichment method is presented to complement current phosphopeptide isolation strategies that normally bias mass spectrometry analysis towards the detection of mono-phosphopeptides. An adsorption model is developed that show ...

2010

Macroporous Materials as Novel Catalysts for Efficient and Controllable Proteolysis

Liang Qiao, Jingjing Wan, Jiawei Tang

A novel nanopore based digestion strategy has been developed by directly adding a macroporous material as catalyst to the conventional in-solution reaction system. Without increasing the enzyme or protein concentrations, this simple digestion approach exhi ...

American Chemical Society2009

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Chemical specificity

Deamidation and Transamidation of Substance P by Tissue Transglutaminase Revealed by Electron-Capture Dissociation Fourier Transform Mass Spectrometry (Chem. Eur. J. 2/2011)

Fetal Epiphyseal Chondrocytes Behavior within 3D Hydrogels

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

Two-Dimensional Polymer Formation on Surfaces: Insight into the Roles of Precursor Mobility and Reactivity

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Force spectroscopy of barnase-barstar single molecule interaction

Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry

Macroporous Materials as Novel Catalysts for Efficient and Controllable Proteolysis

Graph Chatbot

Chattez avec Graph Search

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

Two-Dimensional Polymer Formation on Surfaces: Insight into the Roles of Precursor Mobility and Reactivity

Force spectroscopy of barnase-barstar single molecule interaction

Macroporous Materials as Novel Catalysts for Efficient and Controllable Proteolysis

Deamidation and Transamidation of Substance P by Tissue Transglutaminase Revealed by Electron-Capture Dissociation Fourier Transform Mass Spectrometry (Chem. Eur. J. 2/2011)

Fetal Epiphyseal Chondrocytes Behavior within 3D Hydrogels

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry