Publications associées à Excitatory synapse

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

T he inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system ...

Rockefeller University Press2010

Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice

Carl Petersen, Michael Avermann, Ferenc Mátyás

Computations in cortical circuits are mediated by synaptic interactions between excitatory and inhibitory neurons, and yet we know little about their activity in awake animals. Here, through single and dual whole-cell recordings combined with two-photon mi ...

Elsevier2010

Interaction between Facilitation and Depression at a Large CNS Synapse Reveals Mechanisms of Short-Term Plasticity

Ralf Schneggenburger, Olexiy Kochubey, Martin Guillermo Mueller

The two fundamental forms of short-term plasticity, short-term depression and facilitation, coexist at most synapses, but little is known about their interaction. Here, we studied the interplay between short-term depression and facilitation at calyx of Hel ...

Society for Neuroscience2010

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Carl Petersen, Juan-Carlos Sarria, Sandrine Lefort, Christian Tomm

Local microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex ...

2009

Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain

Rolf Gruetter, Hongxia Lei

Evolution of the neurochemical profile consisting of 19 metabolites after 30 mins of middle cerebral artery occlusion was longitudinally assessed at 3, 8 and 24 h in 6 to 8 mu L volumes in the striatum using localized H-1-magnetic resonance spectroscopy at ...

Nature Publishing Group2009

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Ozgün Gökce, Nikita Rudinskiy, Nicole Déglon

Hippocalcin is a neuronal calcium sensor protein previously implicated in regulating neuronal viability and plasticity. Hippocalcin is the most highly expressed neuronal calcium sensor in the medium spiny striatal output neurons that degenerate selectively ...

Wiley-Blackwell2009

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

Harald Hirling, Nikita Rudinskiy

Clathrin-dependent endocytosis is mediated by a tightly regulated network of molecular interactions that provides essential protein-protein and protein-lipid binding activities. Here we report the hydrolysis of the alpha- and beta2-subunits of the tetramer ...

American Society for Biochemistry and Molecular Biology2009

Spike-Based Reinforcement Learning in Continuous State and Action Space: When Policy Gradient Methods Fail

Wulfram Gerstner, Eleni Vasilaki, Nicolas Frémaux, Walter Senn

Changes of synaptic connections between neurons are thought to be the physiological basis of learning. These changes can be gated by neuromodulators that encode the presence of reward. We study a family of reward-modulated synaptic learning rules for spiki ...

Public Library of Science2009

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Excitatory synapse

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice

Interaction between Facilitation and Depression at a Large CNS Synapse Reveals Mechanisms of Short-Term Plasticity

Structure and function of the olfactory bulb microcircuit

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

Spike-Based Reinforcement Learning in Continuous State and Action Space: When Policy Gradient Methods Fail

Graph Chatbot

Chattez avec Graph Search

Structure and function of the olfactory bulb microcircuit

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Interaction between Facilitation and Depression at a Large CNS Synapse Reveals Mechanisms of Short-Term Plasticity

Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain

Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

Spike-Based Reinforcement Learning in Continuous State and Action Space: When Policy Gradient Methods Fail