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Sorbitol

Publications associées (22)

New tool for studying the biosynthetic role of glucose in brain at the nanometer scale

Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Arnaud Comment, Yuhei Takado, Mojgan Masoodi

Background: The brain consumes a considerable amount of glucose relative to its size. Brain glucose is a source of energy, mainly via oxidative phosphorylation, as well as a source of building blocks for synthesising macromolecules. Little is known about t ...

2014

Direct mapping of 19F in 19FDG-6P in brain tissue at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Carole Poitry-Yamate

Low energy x-ray fluorescence (LEXRF) detection was optimized for imaging cerebral glucose metabolism by mapping the fluorine LEXRF signal of 19 F in 19 FDG, trapped as intracellular 19 F-deoxyglucose-6-phosphate ( 19 FDG-6P) at 1μm spatial resolution from ...

2013

Bioethanol production from oil palm empty fruit bunches

Simone Chiesa

Face to the increasing demand for energy, the declining availability of fossil fuels and the periodical tensions in the geopolitical context of oil-producing countries have raised serious concerns in the governments worldwide as well as in the public opini ...

EPFL2012

Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents

Bernard Lanz

Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...

EPFL2012

In vivo magnetic resonance studies of glycogen and hyperpolarized lithium in the rat brain

Ruud van Heeswijk

Nuclear magnetic resonance (NMR) is used for a large array of applications, ranging from chemical characterization to oil drilling to medical imaging. In these fields NMR is used as an investigational tool, but new techniques and applications are continuou ...

EPFL2009

Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Carmen Jungo

The objective of this thesis was to characterize the growth stoichiometry, the specific recombinant protein productivity and the regulation of the alcohol oxidase (AOX) enzyme of a Pichia pastoris Mut+ strain, performing conventional chemostat cultures and ...

EPFL2007

Human brain glycogen content and metabolism: Implications on its role in brain energy metabolism

Rolf Gruetter, Ajay Kumar

The adult brain relies on glucose for its energy needs and stores it in the form of glycogen, primarily in astrocytes. Animal and culture studies indicate that brain glycogen may support neuronal function when the glucose supply from the blood is inadequat ...

2007

Systeme capteur destine a la determination de la glycemie

Peter Ryser, Jacques Jacot, Sigfrid Straessler

The sensor, to determine the concentration of glucose in blood, is implanted within an ampoule (1) containing a sensitive liquid. Glucose can penetrate into the ampoule through its cellulose mantle (2), where the viscosity of the liquid and glucose mixture ...

2004

Lactate is a preferential oxidative energy substrate over glucose for neurons in culture

Pierre Magistretti, Luc Pellerin

The authors investigated concomitant lactate and glucose metabolism in primary neuronal cultures using 13C- and 1H-NMR spectroscopy. Neurons were incubated in a medium containing either [1-13C]glucose and different unlabeled lactate concentrations, or unla ...

2003

Noninvasive measurements of [1-13C]glycogen concentrations and metabolism in rat brain in vivo

Rolf Gruetter

Using a specific 13C NMR localization method, 13C label incorporation into the glycogen C1 resonance was measured while infusing [1- 13C]glucose in intact rats. The maximal concentration of [1-13C]glycogen was 5.1 ± 0.6 μmol g-1 (mean ± SE, n = 8). During ...

1999

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