Radius (os) | EPFL Graph Search

Le radius (du latin, radius, « rayon »), est un os long interne du zeugopode du membre chiridien des vertébrés tétrapodes. Chez l'Homme, le radius constitue, avec l'ulna, l'avant-bras dont il occupe la partie latérale. Il s'articule au niveau du coude avec l'humérus et l'ulna, et au niveau du poignet avec l'ulna, l'os scaphoïde et l'os lunatum. L'ulna et le radius jouent un rôle fondamental dans le mouvement de pronation / supination de l'avant-bras. Il est constitué d'un corps (la diaphyse) et de deux extrémités (les épiphyses proximale et distale). Description Diaphyse La diaphyse ou corps du radius est de section triangulaire. Il est plus étroit en haut qu'en bas. Il est légèrement incurvé en étant convexe latéralement. Il présente trois faces (antérieure, postérieure et latérale) et trois bords (antérieur, postérieur et interosseux). Face antérieure vignette|200x200px|Vue antérieure du radius droit.|gauche La face antérieure ou face palmair

Hand exoskeleton device

Luca Randazzo

The invention relates to a hand exoskeleton device having a modular nature. The device is designed to be wearable, portable and light in weight, and comprises from one to ten modules each having an actuating mechanism such as a linear actuator coupled with an artificial tendon having a flexible cable or shaft encased into a sheath and an elastic, stretchable portion on its distal end. The exoskeleton allows controlling flexion-extension of the fingers, while keeping natural somatosensorial interactions with the environment surrounding the users. The device is useful to e.g. assist and restore hand functions of users with motor disabilities both during activities of daily living and in neurorehabilitative scenarios, as well in other scenarios such as virtual reality.

2019

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord

Daniela Biziato, Michele De Palma, Ferdinando Pucci

Transplanted neural stem/precursor cells possess peculiar therapeutic plasticity and can simultaneously instruct several therapeutic mechanisms in addition to cell replacement. Here, we interrogated the therapeutic plasticity of neural stem/precursor cells after their focal implantation in the severely contused spinal cord. We injected syngeneic neural stem/precursor cells at the proximal and distal ends of the contused mouse spinal cord and analysed locomotor functions and relevant secondary pathological events in the mice, cell fate of transplanted neural stem/precursor cells, and gene expression and inflammatory cell infiltration at the injured site. We used two different doses of neural stem/precursor cells and two treatment schedules, either subacute (7 days) or early chronic (21 days) neural stem/precursor cell transplantation after the induction of experimental thoracic severe spinal cord injury. Only the subacute transplant of neural stem/precursor cells enhanced the recovery of locomotor functions of mice with spinal cord injury. Transplanted neural stem/precursor cells survived undifferentiated at the level of the peri-lesion environment and established contacts with endogenous phagocytes via cellular-junctional coupling. This was associated with significant modulation of the expression levels of important inflammatory cell transcripts in vivo. Transplanted neural stem/precursor cells skewed the inflammatory cell infiltrate at the injured site by reducing the proportion of 'classically-activated' (M1-like) macrophages, while promoting the healing of the injured cord. We here identify a precise window of opportunity for the treatment of complex spinal cord injuries with therapeutically plastic somatic stem cells, and suggest that neural stem/precursor cells have the ability to re-programme the local inflammatory cell microenvironment from a 'hostile' to an 'instructive' role, thus facilitating the healing or regeneration past the lesion.

2012

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord

Daniela Biziato, Michele De Palma, Ferdinando Pucci

2012