Publications associées à Gène de novo

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Jacques Fellay, Amalio Telenti, Istvan Bartha, Nimisha Chaturvedi

Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...

Public Library Science2015

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Vassily Hatzimanikatis, Stepan Tymoshenko, Rebecca Oppenheim, Jens Nielsen, Dominique Soldati-Favre

Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstr ...

Public Library Science2015

The genetics of social hierarchies

Maria del Carmen Sandi Perez, Michael van der Kooij

The organization of individuals in social hierarchies is ubiquitous in social species. Although the evolution of dominance at the population level is constrained by its interactive character, selective breeding shows that dominance and subordination can be ...

2015

Construction of pDYN6902, a new Streptomyces integrative expression vector designed for cloning sequences interfering with Escherichia coli viability

Julien Hiblot, Pierre Leblond

We describe here the construction of a new version of the Escherichia coli-Streptomyces shuttle cloning vector pIJ6902, which carries the original thiostrepton-inducible PtipA as well as the integrative and cloning systems, but with the E. coil low copy nu ...

Academic Press Inc Elsevier Science2015

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

Jacques Rougemont, Philippe Jacquet

Previous studies indicate that eukaryotic promoters display a stereotypical chromatin landscape characterized by a well-positioned +1 nucleosome near the transcription start site and an upstream 1 nucleosome that together demarcate a nucleosome-free (or -d ...

Elsevier2015

Whole genome duplications and recruitment of ecologically relevant genes in alpine Mustards

Stéphane Joost, Kevin Leempoel, Béatrice North

Polyploid taxa represent excellent models to address the underpinnings of genome evolution and the building up of new species in heterogeneous environments. Here, we present an overview of recent works in the alpine Biscutella laevigata autopolyploid compl ...

2015

An Exact Algorithm to Compute the DCJ Distance for Genomes with Duplicate Genes

Bernard Moret, Yu Lin, Mingfu Shao

Computing the edit distance between two genomes is a basic problem in the study of genome evolution. The double-cut-and-join (DCJ) model has formed the basis for most algorithmic research on rearrangements over the last few years. The edit distance under t ...

Springer Verlag2014

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

Bruno Lemaitre, Nichole Broderick

To elucidate mechanisms underlying the complex relationships between a host and its microbiota, we used the genetically tractable model Drosophila melanogaster. Consistent with previous studies, the microbiota was simple in composition and diversity. Howev ...

American Society for Microbiology2014

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Gène de novo

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

The genetics of social hierarchies

Construction of pDYN6902, a new Streptomyces integrative expression vector designed for cloning sequences interfering with Escherichia coli viability

Defining the nitrogen regulated transcriptome of Mycobacterium smegmatis using continuous culture

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

Whole genome duplications and recruitment of ecologically relevant genes in alpine Mustards

An Exact Algorithm to Compute the DCJ Distance for Genomes with Duplicate Genes

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

Predicting the genes regulated by microRNAs via binding sites in the 3' untranslated and coding regions

Graph Chatbot

Chattez avec Graph Search

The genetics of social hierarchies

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

Predicting the genes regulated by microRNAs via binding sites in the 3' untranslated and coding regions

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Construction of pDYN6902, a new Streptomyces integrative expression vector designed for cloning sequences interfering with Escherichia coli viability

Defining the nitrogen regulated transcriptome of Mycobacterium smegmatis using continuous culture

Whole genome duplications and recruitment of ecologically relevant genes in alpine Mustards

An Exact Algorithm to Compute the DCJ Distance for Genomes with Duplicate Genes

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology