Concept
Glutamine
Publications associées (44)
New insights into rodent brain microstructure and metabolism in hepatic encephalopathy
Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...
EPFL2023Dissecting the role of the asparagine synthesis in acute liver injury
Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...
EPFL2022Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans
Rolf Gruetter, Maria del Carmen Sandi Perez, Lijing Xin, Gediminas Luksys, Alina Veronika Irene Strasser
Substantial evidence implicates the nucleus accumbens in motivated performance, but very little is known about the neurochemical underpinnings of individual differences in motivation. Here, we applied 1H magnetic resonance spectroscopy (1H-MRS) at ultra-hi ...
2020Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by (13)C Magnetic Resonance Spectroscopy
Rolf Gruetter, João Miguel das Neves Duarte, Sarah Catherine Sonnay, Freya-Merret Girault
Type 2 diabetes (T2D) is associated with deterioration of brain structure and function. Here, we tested the hypothesis that T2D induces a reorganization of the brain metabolic networks that support brain function. For that, alterations of neuronal and glia ...
2019Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Hongxia Lei, Carole Poitry-Yamate, Elisabeth Anne Dirren
In vivo (1)H magnetic resonance spectroscopy ((1)H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to longitudinally follow neur ...
2019Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism
Lijing Xin, João Miguel das Neves Duarte
In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in ne ...
2019Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states
ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in the plasma membrane in cells of various tissues and tissue barriers, including the blood-brain, blood-testis and maternal-fetal barriers(1-4). Powered by ATP, it t ...
Springer Nature America, Inc2018In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose
Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Carole Poitry-Yamate, Marta Lai, Corina Mihaela Berset
In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...
2018