Glutamine

Science de la nature
Biologie
Biologie cellulaire
Biosynthèse des protéines

Publications associées (30)

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Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex

Rolf Gruetter, Nathalie Just, Sarah Catherine Sonnay, Gregor Rainer, João Miguel das Neves Duarte, Anne Catherine Clerc

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...

Wiley-Blackwell2018

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Benjamin Dieter Weger, Meltem Weger

Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficienc ...

2018

In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Carole Poitry-Yamate, Marta Lai, Corina Mihaela Berset

In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...

2018

MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

Cristina Ramona Cudalbu, Bernard Lanz, Veronika Rackayová

In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, a ...

Elsevier2017

Energy metabolism in the rat cortex under thiopental anaesthesia measured

Rolf Gruetter, Nathalie Just, João Miguel das Neves Duarte, Sarah Catherine Sonnay

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Wiley-Blackwell2017

Experimental and theoretical studies on electropolymerization of polar amino acids on platinum electrode

Christophe Roussel

The anodic oxidation of polar amino acids (L-serine, L-threonine, L-asparagine, and L-glutamine) in aqueous electrolyte on smooth platinum electrode was carried out by cyclic voltammetry coupled to electrochemical quartz crystal microbalance (EQCM). pH (zw ...

Elsevier2017

Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex

Rolf Gruetter, Alberto Corcoba, Kim Do, João Miguel das Neves Duarte

Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects ...

Wiley-Blackwell2017

Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo

Sarah Catherine Sonnay

Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...

EPFL2017

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Johan Auwerx, Kristina Schoonjans, Arnaud Comment, Hadrien Charles Edouard Demagny, Dongryeol Ryu, Xu Wang, Emine Can, Norman Lionel Moullan, Pan Xu, Matthias Alexander Sokrates Stein

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...

Cold Spring Harbor Laboratory2016

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

Pan Xu

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Gaining insight into the molecular pathways involved in the development of HCC is hence a prerequisite to design and develop novel and effective therapeutic strategies. ...

EPFL2016

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