Concept

Glutamine

Publications associées (44)

Ammonia toxicity to the brain

Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in childhood than in adulthood. Hyperammonemia provokes irreversible damage to the ...

Springer Verlag2013

Development and implementation of ¹H magnetic resonance techniques for an improved in vivo assessment of models of cerebral metabolic disorders

Mélanie Craveiro

Nuclear magnetic resonance (NMR) is a physical phenomenon that is widely used in the biomedical field due to its non-invasive and non-destructive properties, which make it an optimal tool for the in vivo investigation of living organs such as the brain. Th ...

EPFL2013

Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Yves Pilloud, João Miguel das Neves Duarte

Brain glutamine synthetase (GS) is an integral part of the glutamate-glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites ...

Nature Publishing Group2012

Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Yashas Rajendra, Divor Kiseljak

For most cultivated mammalian cells, glutamine is an essential medium component. However, glutamine consumption results in the production of ammonia, a cytotoxic byproduct. Here we investigated the effect of glutamine reduction on recombinant protein produ ...

Springer Netherlands2012

Phage Selection of Bicyclic Peptide Ligands and Development of a New Peptide Cyclisation Method

Jeremy Touati

Bicyclic peptides binding to targets of interest can be isolated from combinatorial libraries using a phage display-based approach. In a first project of this thesis, we aimed at generating bicyclic peptide inhibitors of matrix metalloproteinases (MMPs), a ...

EPFL2012

Effect of manganese chloride on the neurochemical profile of the rat hypothalamus

Rolf Gruetter, Cristina Ramona Cudalbu, Hongxia Lei, Nathalie Just

Manganese (Mn 2+)-enhanced magnetic resonance imaging studies of the neuronal pathways of the hypothalamus showed that information about the regulation of food intake and energy balance circulate through specific hypothalamic nuclei. The dehydration-induce ...

Nature Publishing Group2011

Glial Energy Metabolism: A NMR Spectroscopy Perspective

Rolf Gruetter

Oxygen metabolism is uniquely compartmentalized between neurons and glia, the latter comprising about 25% of neuronal energy metabolism. The consumption of acetate and fixation of CO2 in glutamine occur in astrocytes by oxygen-dependent reactions, which po ...

Elsevier2009

Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Gilles Broccard

The objective of this study was to develop a model for the growth of Chinese Hamster Ovary (CHO) cells in shaken bioreactors. For this purpose a modified three parameters Gompertz equation was used to fit lag, exponential and stationary growth phases. Usin ...

2009

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

Patrick Aebischer, Nicole Déglon

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expansion of glutamine repeats in the huntingtin (htt) protein. Abnormal protein folding and the accumulation of mutated htt are hallmarks of HD neuropathology. Heat-shock pr ...

Elsevier2007

CdSe Sensitized Thin Aqueous Films: Probing the Potential Distribution Inside Multilayer Assemblies

Hubert Girault, Bin Su, Mohamad Hojeij, Nicolas Eugster

Ultrathin polypeptide multilayer films are assembled by the sequential electrostatic adsorption of monolayers of poly-L-lysine and poly-L-glutamic acid onto carboxylic acid terminated alkanethiol-modified gold surfaces. The polypeptide multilayer films are ...

American Chemical Society2006

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