Concept

Human evolutionary genetics

Publications associées (37)

Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

Didier Trono, Isabelle Barde, Sonia Verp, Marc Samuel Friedli

Comparative analyses of various mammalian genomes have identified numerous conserved non-coding (CNC) DNA elements that display striking conservation among species, suggesting that they have maintained specific functions throughout evolution. CNC function ...

Public Library of Science2011

Variation in Transcription Factor Binding Among Humans

Differences in gene expression may play a major role in speciation and phenotypic diversity. We examined genome-wide differences in transcription factor (TF) binding in several humans and a single chimpanzee by using chromatin immunoprecipitation followed ...

American Association for the Advancement of Science2010

Systematic Inference of Copy-Number Genotypes from Personal Genome Sequencing Data Reveals Extensive Olfactory Receptor Gene Content Diversity

Sebastian Martin Waszak

Copy-number variations (CNVs) are widespread in the human genome, but comprehensive assignments of integer locus copy-numbers (i.e., copy-number genotypes) that, for example, enable discrimination of homozygous from heterozygous CNVs, have remained challen ...

Public Library of Science2010

Where sound position influences sound object representations: A 7-T fMRI study

Rolf Gruetter, Wietske Van der Zwaag, Stephanie Clarke

Evidence from human and non-human primate studies supports a dual-pathway model of audition, with partially segregated cortical networks for sound recognition and sound localisation, referred to as the What and Where processing streams. In normal subjects, ...

Elsevier2010

Innate Barriers to Genome Invasion

Pierre Maillard

Over the course of evolution, retroviruses and their hosts have been in constant conflict, resulting in a long-term evolutionary "arms race" in which host and pathogen alternately gain selective advantages through functional innovations. On the host side, ...

EPFL2010

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

Johan Auwerx

Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human association studies might prove powerful and was exploit ...

Public Library of Science2009

Common genetic variation and the control of HIV-1 in humans

Jacques Fellay, Patrick Descombes, Amalio Telenti

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the ...

2009

A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: A cohort allelic sums test (CAST)

Stephan Morgenthaler

A method is described to discover if a gene carries one or more allelic mutations that confer risk for any specified common disease. The method does not depend upon genetic linkage of risk-conferring mutations to high frequency genetic markers such as sing ...

2007

Rendering massive real-time crowds

Pablo Stanislaw De Heras Ciechomski

This thesis presents how to visualize a large crowd of virtual human characters in real time on a standard issue personal computer. The virtual humans are distributed into rendering fidelities such that the humans closer to the viewer are detailed and expr ...

EPFL2006

Prediction of Regulatory Modules Comprising MicroRNAs and Target Genes

Giovanni De Micheli

Motivation: MicroRNAs are small endogenous RNAs that can play important regulatory roles via the RNA-interference pathway by targeting mRNAs for cleavage or translational repression. We propose a computational method to predict miRNA regulatory modules or ...

2005

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