Publications associées à Broméline

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Bruno Lemaitre, Maroun Bou Sleiman, Olivier Binggeli, Lise Bertin

Melanization contributes to arthropod-specific innate immunity through deposition of melanin at wound sites or around parasites, with concomitant release of microbicidal reactive oxygen species. Melanization requires sequential activation of proteolytic en ...

Elsevier2015

Amino-functionalized macroporous silica for efficient tryptic digestion in acidic solutions

Hubert Girault, Liang Qiao, Jingjing Wan

Amino-functionalized macroporous silica foam (NH2-MOSF) has been developed as a host reactor to realize highly efficient proteolysis in acidic solutions where normal tryptic reactions cannot occur. The digestion protocol consists simply of adding the funct ...

Wiley-Blackwell2013

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies

Lorène Aeschbach, Patrick Fraering, Mitko Dimitrov, Claude André Schweizer

A detailed understanding of γ-secretase structure is crucially needed to elucidate its unique properties of intramembrane protein cleavage and to design therapeutic compounds for the safe treatment of Alzheimer's disease. γ-Secretase is an enzyme complex c ...

Amer Chemical Soc2012

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil, Andrija Finka

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Substrate-targeting gamma-secretase modulators

Patrick Fraering

Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease ...

Nature Publishing Group2008

Formation of Microcapsules from Polyelectrolyte and Covalent Interactions

Urs von Stockar, Ian William Marison, Véronique Breguet, Raphaël Gugerli, Mimma Pernetti

A new approach combining electrostatic and covalent bonds was established for the formation of resistant capsules with long-term stability under physiol. conditions. Three kinds of interactions were generated in the same membrane: (1) electrostatic bonds b ...

2005

The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity

Françoise Gisou van der Goot Grunberg

Vibrio and Aeromonas spp. secrete an unusual 35-kDa lipase that shares several properties with mammalian lecithin-cholesterol acyltransferase. The Aeromonas hydrophila lipase contains two cysteine residues that form an intramolecular disulfide bridge. Here ...

1997

Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: identification of the site of proteolytic activation

Françoise Gisou van der Goot Grunberg

The channel-forming protein aerolysin is secreted as a protoxin which can be activated by proteolytic removal of a C-terminal peptide. The activation and subsequent oligomerization of aerolysin were studied using a variety of spectroscopic techniques. Mass ...

1992

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Broméline

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Amino-functionalized macroporous silica for efficient tryptic digestion in acidic solutions

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Substrate-targeting gamma-secretase modulators

Formation of Microcapsules from Polyelectrolyte and Covalent Interactions

The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity

Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: identification of the site of proteolytic activation

The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers

Graph Chatbot

Chattez avec Graph Search

Substrate-targeting gamma-secretase modulators

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity

Amino-functionalized macroporous silica for efficient tryptic digestion in acidic solutions

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies

The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers

Formation of Microcapsules from Polyelectrolyte and Covalent Interactions

Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: identification of the site of proteolytic activation