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Publications associées (86)

Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

Florian Maria Wurm, David Hacker, Sowmya Balasubramanian

Heterogenous populations of recombinant cells (cell pools) stably expressing 1-4 transgenes were generated from Chinese hamster overy (CHO) cells with the piggyBac (PB) transposon system. The cell pools produced different combinations of three model protei ...

American Chemical Society2016

On the importance of skewed offspring distributions and background selection in virus population genetics

Kristen Kay Irwin, Jeffrey David Jensen, Séverine Vuilleumier Varisco, Claudia Bank, Sebastian Matuszewski, Stefan Jean Laurent, Hyunjin Shim, Nicky Louise Ormond

Many features of virus populations make them excellent candidates for population genetic study, including a very high rate of mutation, high levels of nucleotide diversity, exceptionally large census population sizes, and frequent positive selection. Howev ...

Nature Publishing Group2016

Inferring the age of a fixed beneficial allele

Jeffrey David Jensen, Matthieu Foll, Susanne Petra Pfeifer, Nicky Louise Ormond, Gregory Bruce Ewing

Estimating the age and strength of beneficial alleles is central to understanding how adaptation proceeds in response to changing environmental conditions. Several haplotype-based estimators exist for inferring the age of segregating beneficial mutations. ...

Wiley-Blackwell2016

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans

Matthieu Foll

Tropical forests are believed to be very harsh environments for human life. It is unclear whether human beings would have ever subsisted in those environments without external resources. It is therefore possible that humans have developed recent biological ...

Public Library of Science2015

Storage selection functions: A coherent framework for quantifying how catchments store and release water and solutes

Andrea Rinaldo, Paolo Benettin, Enrico Bertuzzo, Gianluca Botter

We discuss a recent theoretical approach combining catchment-scale flow and transport processes into a unified framework. The approach is designed to characterize the hydrochemistry of hydrologic systems and to meet the challenges posed by empirical eviden ...

Amer Geophysical Union2015

The composite twin Higgs scenario

Riccardo Rattazzi, Andrea Wulzer, Davide Greco

Based on an explicit model, we propose and discuss the generic features of a possible implementation of the Twin Higgs program in the context of composite Higgs models. We find that the Twin Higgs quadratic divergence cancellation argument can be uplifted ...

Springer2015

On Non-cooperative Genomic Privacy

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday

Over the last few years, the vast progress in genome sequencing has highly increased the availability of genomic data. Today, individuals can obtain their digital genomic sequences at reasonable prices from many online service providers. Individuals can st ...

2015

Interdependent Privacy Games: The Case of Genomics

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday

2015

Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective

Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Hyunjin Shim, Gregory Bruce Ewing, Anna Ferrer Admetlla

Author Summary In recent years, considerable attention has been given to the evolution of drug resistance in the influenza A H1N1 strain. As a major annual cause of morbidity and mortality, combined with the rapid global spread of drug resistance, influenz ...

Public Library of Science2014

On the Prospect of Identifying Adaptive Loci in Recently Bottlenecked Populations

Jeffrey David Jensen

Identifying adaptively important loci in recently bottlenecked populations - be it natural selection acting on a population following the colonization of novel habitats in the wild, or artificial selection during the domestication of a breed - remains a ma ...

Public Library of Science2014

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