Concept

P14arf

Publications associées (42)

An online intrinsic stabilization strategy for the reduced basis approximation of parametrized advection-dominated problems

Alfio Quarteroni, Andrea Manzoni, Yvon Maday

We propose a new, black-box online stabilization strategy for reduced basis (RB) approximations of parameter-dependent advection-diffusion problems in the advection-dominated case. Our goal is to stabilize the RB problem irrespectively of the stabilization ...

Elsevier France-Editions Scientifiques Medicales Elsevier2016

Fingerprinting the reactive toxicity pathways of 50 drinking water disinfection by-products

Urs von Gunten

A set of nine in vitro cellular bioassays indicative of different stages of the cellular toxicity pathway was applied to 50 disinfection by-products (DBPs) to obtain a better understanding of the commonalities and differences in the molecular mechanisms of ...

Elsevier2016

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression

Michele De Palma, Mario Leonardo Squadrito

microRNAs (miRNAs) are short non-coding RNAs, which regulate gene expression post-transcriptionally and play crucial roles in relevant biological and pathological processes. Here we investigated the putative role of miRNAs in modulating the tumor-initiatin ...

Wiley-Blackwell2015

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells

Jie Chen, Cyrille Dunant

Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanism ...

Cell Press2015

Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy

Elisa Oricchio, Giovanni Ciriello

Loss of cell cycle controls is a hallmark of cancer and has a well-established role in aggressive B cell malignancies. However, the role of such lesions in indolent follicular lymphoma (FL) is unclear and individual lesions have been observed with low freq ...

2014

Post-translational regulation enables robust p53 regulation

Ali H. Sayed

The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuatio ...

BioMed Central2013

Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammat ...

2012

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

Etienne Meylan

Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets are poorly understood. Caspase-2 is activated by the p53 target gene product PIDD (also known as LRDD) in a complex called the Caspase-2-PIDDosome. We show t ...

2011

Marker-independent identification of glioma-initiating cells

Rolf Gruetter, Cristina Ramona Cudalbu

Tumor-initiating cells with stem cell properties are believed to sustain the growth of gliomas, but proposed markers such as CD133 cannot be used to identify these cells with sufficient specificity. We report an alternative isolation method purely based on ...

Nature Publishing Group2010

Ink-dependent n-factors for the Yule-Nielsen modified spectral Neugebauer model

Roger Hersch, Romain Rossier

Different inks may have different mechanical and/or optical properties. Existing Yule-Nielsen modified Neugebauer spectral prediction models assume however that the inks forming a color halftone behave similarly, i.e. that a single n-factor can model the l ...

Society for Imaging Science and Technology2010

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