Concept
Plaque motrice
Publications associées (76)
Trio preserves motor synapses and prolongs motor ability during aging
Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Greta Limoni, Samuel William Vernon, Wei Jiao
The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age -dependent structural fragmentation co -incident with dim ...
Cell Press2024Evaluation of antigravitational support levels provided by a passive upper-limb occupational exoskeleton in repetitive arm movements
Upper-limb occupational exoskeletons to support the workers' upper arms are typically designed to provide antigravitational support. Although typical work activities require workers to perform static and dynamic actions, the majority of the studies in lite ...
London2024Novel Design and Implementation of a Neuromuscular Controller on a Hip Exoskeleton for Partial Gait Assistance
Auke Ijspeert, Mohamed Bouri, Ali Reza Manzoori, Andrea Di Russo, Sara Messara
Exoskeletons intended for partial assistance of walking should be able to follow the gait pattern of their users, via online adaptive control strategies rather than imposing predefined kinetic or kinematic profiles. NeuroMuscular Controllers (NMCs) are ada ...
2023Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics
Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon degeneration in Hereditary Spastic Paraplegia (HSP). We therefore asked how ...
New York2023Neuromodulation of neocortical microcircuitry: a multi-scale framework to model the effects of cholinergic release
Neuromodulation of neocortical microcircuits is one of the most fascinatingand mysterious aspects of brain physiology. Despite over a century of research,the neuroscientific community has yet to uncover the fundamentalbiological organizing principles under ...
EPFL2022Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)
Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates,such as fish, and potentially cause neurotoxic effects. Although these ...
EPFL2022Wearable High-Density MXene-Bioelectronics for Neuromuscular Diagnostics, Rehabilitation, and Assistive Technologies
Silvestro Micera, Francesco Iberite, Eugenio Anselmino
High-density surface electromyography (HDsEMG) allows noninvasive muscle monitoring and disease diagnosis. Clinical translation of current HDsEMG technologies is hampered by cost, limited scalability, low usability, and minimal spatial coverage. Here, this ...
WILEY-V C H VERLAG GMBH2022REM sleep and muscle atonia in brainstem stroke: A quantitative polysomnographic and lesion analysis study
Important brainstem regions are involved in the regulation of rapid eye movement sleep. We hypothesized that brainstem stroke is associated with dysregulated rapid eye movement sleep and related muscle activity. We compared quantitative/qualitative polysom ...
WILEY2022Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary target, there is evidence that peripheral organ defects contribute to SMA. Current SMA gene ther ...
2022Mechanotaxis directs Pseudomonas aeruginosa twitching motility
Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Xavier Jean-Yves Pierrat, Jose Negrete Jr, Joanne Netter Engel, Marco Julian Kühn
The opportunistic pathogen Pseudomonas aeruginosa explores surfaces using twitching motility powered by retractile extracellu-lar filaments called type IV pili (T4P). Single cells twitch by sequen-tial T4P extension, attachment, and retraction. How single ...
NATL ACAD SCIENCES2021