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Homeostatic plasticity

Publications associées (155)

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Mauro Pulin

Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...
Nature Portfolio2024

Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala

Henry Markram, Rodrigo de Campos Perin

The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...
Nature Portfolio2024

Long-term plasticity induces sparse and specific synaptic changes in a biophysically detailed cortical model

Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Marwan Muhammad Ahmed Abdellah, Pramod Shivaji Kumbhar, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander, Jorge Blanco Alonso, Giuseppe Chindemi, Ioannis Magkanaris

Synaptic plasticity underlies the brain’s ability to learn and adapt. This process is often studied in small groups of neurons in vitro or indirectly through its effects on behavior in vivo. Due to the limitations of available experimental techniques, inve ...
2023

Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network

Friedhelm Christoph Hummel, Estelle Emeline Raffin, Michele Bevilacqua

Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single-pulse transcranial magnetic stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway an ...
2023

Principles of Network Plasticity in Neocortical Microcircuits

András Ecker

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...
EPFL2023

Engram cell connectivity as a mechanism for information encoding and memory function

Maurizio Ferdinando Pezzoli

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...
Cambridge2023

A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model

Disruption of brain development early in life may underlie the neurobiology behind schizophre-nia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult Roman High-Avoidance (RHA-I) rats, a behavioural model displaying schizoph ...
2023

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Matthias Wolf, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Werner Alfons Hilda Van Geit, James Gonzalo King, Pramod Shivaji Kumbhar, Alexis Arnaudon, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Armando Romani, András Ecker, Michael Emiel Gevaert, Vishal Sood, Sirio Bolaños Puchet, James Bryden Isbister, Judit Planas Carbonell, Daniela Egas Santander, Maria Reva, Genrich Ivaska, Natali Barros Zulaica, Mustafa Anil Tuncel, Christoph Pokorny, Elvis Boci, Jorge Blanco Alonso, Aleksandra Zuzanna Teska, Darshan Mandge, Polina Litvak, Gianluca Ficarelli, Weina Ji, Giuseppe Chindemi, Christian Andreas Rössert, Omar Awile, Joni Henrikki Herttuainen, Samuel Lieven D. Lapere, Thomas Brice Delemontex, Tanguy Pierre Louis Damart, Alexander Dietz

In recent years, large-scale computational models of the cortex have emerged as a powerful way to study the multi-scale mechanisms of neural processing. However, due to computational costs and difficulty of parameterization, detailed biophysical reconstruc ...
2023

Increased functional connectivity in the right dorsal auditory stream after a full year of piano training in healthy older adults

Dimitri Nestor Alice Van De Ville

Learning to play an instrument at an advanced age may help to counteract or slow down age-related cognitive decline. However, studies investigating the neural underpinnings of these effects are still scarce. One way to investigate the effects of brain plas ...
Berlin2023

Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in Developing Xenopus laevis Tadpoles

Andrea Ferrario, Haoyu Zhang

Developing spinal circuits generate patterned motor outputs while many neurons with high membrane resistances are still maturing. In the spinal cord of hatchling frog tadpoles of unknown sex, we found that the firing reliability in swimming of inhibitory i ...
SOC NEUROSCIENCE2023

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