Publications associées à Médecine prédictive

Predicting the Occurrence of Variants in RAG1 and RAG2

Jacques Fellay, Flavia Aurelia Shoko Hodel, Dylan Lawless

While widespread genome sequencing ushers in a new era of preventive medicine, the tools for predictive genomics are still lacking. Time and resource limitations mean that human diseases remain uncharacterized because of an inability to predict clinically ...

2019

Privacy-Enhancing Technologies for Medical and Genomic Data: From Theory to Practice

Jean Louis Raisaro

The impressive technological advances in genomic analysis and the significant drop in the cost of genome sequencing are paving the way to a variety of revolutionary applications in modern healthcare. In particular, the increasing understanding of the human ...

EPFL2018

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Elisa Oricchio, Mohammad Sadegh Saghafinia, Elena Battistello, Daniele Tavernari, Stephanie Jocelyne Sungalee, Franck Claude Raynaud, Giovanni Ciriello, Marco Mina, Titouan Laessle

Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the ...

Cell Press2017

Quantifying Genomic Privacy via Inference Attack with High-Order SNV Correlations

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Zhicong Huang, Sahel Shariati Samani

As genomic data becomes widely used, the problem of genomic data privacy becomes a hot interdisciplinary research topic among geneticists, bioinformaticians and security and privacy experts. Practical attacks have been identified on genomic data, and thus ...

2015

Reconciling Utility with Privacy in Genomics

Jean-Pierre Hubaux, Amalio Telenti, Erman Ayday, Mathias Jacques Jean-Marc Humbert

Direct-to-consumer genetic testing makes it possible for everyone to learn their genome sequences. In order to contribute to medical research, a growing number of people publish their genomic data on the Web, sometimes under their real identities. However, ...

2014

Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384

Paul Jack Mc Laren, Jun Li

Stavudine (d4T) was, until recently, one of the most widely prescribed antiretroviral drugs worldwide. While there has been a major shift away from d4T use in resource-limited countries, a large number of patients have previously received (or continue to r ...

Springer2014

A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA

John Maddocks

It is well recognized that base sequence exerts a significant influence on the properties of DNA and plays a significant role in protein-DNA interactions vital for cellular processes. Understanding and predicting base sequence effects requires an extensive ...

2010

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans

Pierre Gönczy

A key challenge of functional genomics today is to generate well-annotated data sets that can be interpreted across different platforms and technologies. Large-scale functional genomics data often fail to connect to standard experimental approaches of gene ...

2005