Concept
Évolution systématique de ligands par enrichissement exponentiel
Publications associées (35)
RNA-based nanomedicines and their clinical applications
RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases. These include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), endo ...
Beijing2023Divalent Cation Dependence Enhances Dopamine Aptamer Biosensing
Oligonucleotide receptors (aptamers), which change conformation upon target recognition, enable electronic biosensing under high ionic-strength conditions when coupled to field-effect transistors (FETs). Because highly negatively charged aptamer backbones ...
2021Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
John Maddocks, Daiva Petkeviciute, Rahul Sharma, Marco Pasi, Paolo Carloni
The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational ch ...
London2021Site-Specific Protein Conjugation onto Fluorescent Single-Walled Carbon Nanotubes
Ardemis Anoush Boghossian, Shang-Jung Wu, Vitalijs Zubkovs
Semiconducting single-walled carbon nanotubes (SWCNTs) are among the few photostable optical emitters that are ideal for sensing, imaging, drug delivery, and monitoring of protein activity. These applications often require strategies for immobilizing prote ...
2020Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo
The specific interaction between DNA and proteins constitutes one of the crucial elements in the regulation of gene expression. This thesis focuses on the development and optimization of two microfluidic-based technologies called SMiLE-seq and FloChIP that ...
EPFL2019