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Publications associées (344)

Boosting olfactory cocktail-party performance by semi-supervised learning in mice

Mice are excellent at detecting single odor components in complex mixtures. Yet, when they are trained on single odors alone, they fail to reliably detect target odors in mixtures of multiple odorants. This inability was predicted by a linear readout that ...

2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Jun Yong Kim, Dongryeol Ryu, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Karim Laurent Gariani, Pooja Jha

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Angiopoietin-1 deficiency increases tumor metastasis in mice

Iacovos Michael

Background: Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of ...

2017

Displacement rate and structural effects on Poisson ratio of a ductile structural adhesive in tension and compression

Thomas Keller, Anastasios Vassilopoulos, Myrsini Angelidi

The effects of the loading type, i.e. tension or compression, and displacement rate on the Poisson ratio of a non-linear viscoelastic ductile structural adhesive have been investigated using digital image correlation-based strain fields. The results showed ...

Elsevier2017

Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation

Hilal Lashuel, Ritwik Burai

Brain aging and neurodegeneration are associated with prominent microglial reactivity and activation of innate immune response pathways, commonly referred to as neuroinflammation. One such pathway, the type I interferon response, recognizes viral or mitoch ...

Cell Press2017

Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease

Theo Lasser, Tristan Bolmont, Taoufiq Harach, Fabien Louis Claude Robert Jammes, Nicolas Jean Marc Antoine Duthilleul, Valentin Laurent Herbert Zufferey

The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSCs) and factors (stem cell factors) on cerebral amyloid beta (Aβ) pathology was investigated in a mouse model of Alzheimer's disease (AD). To this end, hMSCs were administered intraveno ...

Elsevier2017

Somatosensory Cortex Plays an Essential Role in Forelimb Motor Adaptation in Mice

Alexander Mathis, Mackenzie Mathis

Our motor outputs are constantly re-calibrated to adapt to systematic perturbations. This motor adaptation is thought to depend on the ability to form a memory of a systematic perturbation, often called an internal model. However, the mechanisms underlying ...

2017

A System for In Vivo Imaging of Hepatic Free Fatty Acid Uptake

Grigory Karateev

Alterations in hepatic free fatty acid (FFA) uptake and metabolism contribute to the development of prevalent liver disorders such as hepatosteatosis. However, detecting dynamic changes in FFA uptake by the liver in live model organisms has proven difficul ...

Elsevier2017

Angiotensin II infusion into ApoE(-/-) mice: a model for aortic dissection rather than abdominal aortic aneurysm?

Nikolaos Stergiopoulos, Lydia Aslanidou, Jessica Sordet, Bram Trachet, Alessandra Piersigilli, Patrick Segers

Aims Angiotensin II-infused ApoE(-/-) mice are a popular mouse model for preclinical aneurysm research. Here, we provide insight in the often-reported but seldom-explained variability in shape of dissecting aneurysms in these mice. Methods and results N=45 ...

2017

T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE

Mario Gaetano Lepore, Nathalie Just, Florent Eggenschwiler, Olivier Benoit Thomas Reynaud, Carola Jaquelina del Carmen Romero, Luc Driencourt

With the increasing development of transgenic mouse models of neurodegenerative diseases allowing improved understanding of the underlying mechanisms of these disorders, robust quantitative mapping techniques are also needed in rodents. MP2RAGE has shown g ...

Springer Heidelberg2017

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