Température corporelle humaine

vignette|La température corporelle est principalement ressentie au niveau de la tête. La température corporelle humaine est maintenue constante, l’être humain étant un organisme homéotherme. On considère généralement que la température basale usuelle du corps humain est de , cependant cette valeur dépend de l'endroit du corps où est faite la mesure, de l'instrument de mesure, de l'heure de la journée et du niveau d'activité de la personne. Une température corporelle normale se situe ainsi entre et . Évolution récente de la température interne humaine Au milieu du , le médecin allemand Karl August Wunderlich réalise des travaux sur la fièvre qui contribuent à la mise au point de l’usage du thermomètre en médecine. En 1868, sur la base de relevés concernant et impliquant un million de mesures axillaires, Wunderlich établit dans son ouvrage Les variations thermiques dans les maladies, la température normale du corps humain entre 37 et (plage de 36,2 à pour une personne e

Quantitative microstructural characterisation of concrete cured under realistic temperature conditions

Xinyu Zhang

The curing temperature is known to influence the strength and durability of concrete. In general, curing at elevated temperature results in high early strength gain, but impairs the long-term strength and transport properties. Previous investigations have not provided a complete understanding of these effects; in particular, no quantitative relation between microstructural and macroscopic changes has been developed. This work has adopted a combination of macro and micro characterisation to further a comprehensive and quantitative understanding of the property development under different curing conditions, through approaches which include both qualitative and quantitative microstructural analysis with SEM, EDS, XRD, NMR and TG. A systematic study on several mix designs and curing regimes has been carried out, to relate microstructural properties such as degree of hydration, C-S-H composition, C-S-H relative density and capillary porosity to compressive strength and water sorptivity. The results show that the Ca/(Si+Al) ratio of C-S-H is constant with temperature, and the increase in relative C-S-H brightness is thus attributed to the higher C-S-H density and lower chemically bound water at higher temperatures. The early hydration of concretes is accelerated by high temperatures, but the ultimate value is not limited, as opposed to widely reported lower values in the literature. This discrepancy is explained by the fact that previous workers have assumed that the bound water is constant for different curing temperatures whereas this is not the case. Linear relationships were established between the degree of hydration and the compressive strength of concretes, which depend on curing temperatures and mix design. Through their influence on the density and distribution of hydration products, elevated temperatures increase the ultimate capillary porosity of concretes. The relationship between capillary porosity and compressive strength seems independent of temperature to a first approximation, but no unique relationship is shown between sorptivity and compressive strength. Materials which were exposed to higher temperatures for only short periods of time, such as might be experienced in prefabrication or in the curing of large masses, showed some recovery in both microstructure and mechanical properties from the detrimental effects of high temperature.

EPFL2007

Thermal microsensors for in vitro and in vivo monitoring of chemical and biological processes

Rima Padovani

Metabolism is a highly coordinated biochemical cellular activity indispensable for sustaining life, and is often related to mitochondrial functioning. Innovative technological approaches allowing the study of the thermal signature of chemical and metabolic processes are presented in this thesis. In particular, two solutions are proposed: (i) a nanocalorimetric platform enabling measurements of biochemical heat production in vitro, and (ii) a method for localized in vivo temperature measurements in mice using implantable miniaturized sensors. First, the design and development of the nanocalorimetric platform is presented. In particular, this platform is built around a commercial thermopile-based sensor chip, on which an open-well reservoir holding a sample with a volume of a few tens of microliter is directly positioned. Both components are embedded into an isothermal housing providing an excellent temperature stability (± 1 mK), which is a prerequisite for accurate heat power measurements. Furthermore, the platform is characterized by a fast thermalization time to the target temperature (less than 30 minutes) and a fast sensing response time (a few seconds). Numerical simulations, which allowed the optimization of the platform design, are also reported. Electrical calibration of the platform was carried out using resistive heaters positioned either on the sensor chip or in the sample reservoir. A heat power limit of detection of 70 nW was estimated. Then, two reactions for the validation of the nanocalorimetric platform were investigated: (i) the mixing of 1-propanol in water, and (ii) the oxidation of glucose catalyzed by glucose oxidase. The results showed good agreement with literature, confirming that our versatile platform may be applied to many thermochemical studies, including thermodynamic analysis and kinetic reaction analysis. Furthermore, localized in vivo temperature measurements in mice by means of implantable miniaturized sensors are presented. The aim was to monitor mouse metabolism during cold exposure, and to record possible temperature differences between the body temperature measured in the abdomen and the temperature of the brown adipose tissue (BAT) situated in the interscapular area. This approach is of biological interest as it may help unravelling the question whether biochemical activation of BAT is associated with local increase in metabolic heat production. Specifically, the preparation and calibration of miniaturized thermistor sensors are reported and the surgical procedure is also described. Temperature measurements, carried out on mice during cold exposure (6 °C) for a maximum duration of 6 hours, are presented and analyzed. Control measurements with a conventional probe confirmed the good performance of the implanted sensors. Moreover, analysis of the experimental results allowed the identification of two different mouse phenotypes, distinguishable in terms of their metabolic resistance to cold exposure. This difference was investigated from the thermal point of view by computational simulations. A simple physical model of the mouse body allowed to reproduce the global evolution of hypothermia and to explain qualitatively the temperature difference between abdomen and BAT locations. While with this approach, we have demonstrated the importance and feasibility of localized temperature measurements on mice, further optimization of this technique is foreseen to better identify local metabolism variations.

EPFL2016

Thermo-hydro-mechanical behavior of energy tunnels

Matthias Timothee Stanislas Wojnarowicz

Subsurface geothermal in combination with Ground Heat Exchanger (GHE) and heat pumps systems had proved over the past decade to be an effective way in space heating and cooling. GHE’s embedded in geostructures such as tunnels has become more and more attractive in the current state where we try to mitigate greenhouse gas effects. The scope of this paper is to provide a fully coupled numerical model to assess the different physical aspects of an energy tunnel such as the kinetic and thermal boundaries layers development, thermally induce stress, and the heat generation. To do so, a finite element model is used to assess the heat exchange between, the GHE, the concrete lining, the air within the tunnel, the surrounding ground, and groundwater flow. The numerical model is then confronted with data from real-scale experimentation that was performed in Torino in 2018. The predictions from the numerical model show a quite good match with the data from the experimental prototype. Later on, similar models are generated to assess the effect of the heat exchange on air velocity and temperature within the tunnel as well as the induced thermal stress. The numerical results highlight the formation of both the kinematic and thermal boundary layer and shows that those boundaries are affected by the GHE’s activation. For the kinematic aspect, the lower temperatures observed in the vicinity of the heat exchangers tend to lower the velocity magnitude especially close to the wall surface. This change in velocity may be linked to a buoyancy effect cause by the lower temperature of the air in this regions. Indeed natural convection occurs along the tunnel, cooler fluid is pushed down while the warmer fluid rise; locally a lower temperature tends to decrease the viscosity of the fluid and increase its volumic mass. It was observed that the activation of GHE’s enhances this phenomenon in their vicinity due to the temperature gradient that they produce. Moreover, GHE’s activation tends to increase the overall turbulence of the flow and thus the eddies’ formation. The locations of those disturbance are difficult to predict due to the fact that small disturbance may generate large vorticity within the flow. However, it is shown that after passing the GHE zone, the velocity profile tends to stabilize to the undisturbed case. The kinematic entry length seems to happen further down the stream in the case where GHE’s are activated. This is due to the temperature disturbance generated by GHE’s activation. This phenomenon is increased with respect to the number of GHE loops activated. Furthermore, some probing was performed in the vicinity of the heat exchanger to assess the thermal induce stress due to the heating operation. The recorded stress shows peaks at early stages due to the higher temperature gradient that is generated between the GHE’s and concrete at beginning. Finally, after some time, the temperature reaches a steady state hence the stabilized thermal response recorded.

2020