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Publications associées (25)

Retrospectives on Three Decades of Safe Clinical Experience with Allogeneic Dermal Progenitor Fibroblasts: High Versatility in Topical Cytotherapeutic Care

Corinne Scaletta, Philippe Abdel Sayed, Nathalie Hirt-Burri, Alexis Laurent

Allogeneic dermal progenitor fibroblasts constitute cytotherapeutic contenders for modern cutaneous regenerative medicine. Based on advancements in the relevant scientific, technical, and regulatory fields, translational developments have slowly yet steadi ...

MDPI2023

Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Florian Maria Wurm

Chinese Hamster Ovary [CHO] cells are the workhorse for production of modern biopharmaceuticals. They are however immortalized cells with a high propensity for genetic change. Judging from published culture records, CHO cell populations have undergone hund ...

2021

Active Directional Modifier Adaptation with Trust Region - Application to Energy-Harvesting Kites

Dominique Bonvin, Colin Neil Jones, Matthieu Jonin, Sanket Sanjay Diwale, Martand Singhal

Many real-time optimization schemes maximize process performance by performing a model-based optimization. However, due to plant-model mismatch, the model-based solution is often suboptimal. In modifier adaptation, measurements are used to correct the mode ...

IEEE2018

Real-Time Optimization of Uncertain Process Systems via Modifier Adaptation and Gaussian Processes

Dominique Bonvin, Colin Neil Jones, Timm Faulwasser, Harsh Ambarishkumar Shukla

In the context of static real-time optimization, the use of measurements allows dealing with uncertainty in the form of plant-model mismatch and disturbances. Modifier adaptation (MA) is a measurement-based scheme that uses first-order corrections to the m ...

IEEE2018

On enforcing the necessary conditions of optimality under plant-model mismatch - What to measure and what to adapt?

Martand Singhal

Industrial processes are run with the aim of maximizing economic profit while simultaneously meeting process-critical constraints. To this end, model-based optimization can be performed to ensure optimal plant operations. Usually, inevitable model inaccura ...

EPFL2018

Real-Time Optimization of Interconnected Systems via Modifier Adaptation, with Application to Gas-Compressor Stations

Predrag Milosavljevic

The process industries are characterized by a large number of continuously operating plants, for which optimal operation is of economic and ecological importance. Many industrial systems can be regarded as an arrangement of several subsystems, where outp ...

EPFL2018

Enforcing Model Adequacy in Real-Time Optimization via Dedicated Parameter Adaptation

Dominique Bonvin, Martand Singhal, Afaq Ahmad

Iterative real-time optimization schemes that employ modifier adaptation add bias and gradient correction terms to the model that is used for optimization. These affine corrections lead to meeting the first-order necessary conditions of optimality of the p ...

ELSEVIER SCIENCE BV2018

Modifier adaptation with guaranteed feasibility in the presence of gradient uncertainty

Dominique Bonvin, Timm Faulwasser, Alejandro Gabriel Marchetti, Martand Singhal

In the context of real-time optimization, modifier-adaptation schemes use estimates of the plant gradients to achieve plant optimality despite plant-model mismatch. Plant feasibility is guaranteed upon convergence, but not at the successive operating point ...

Pergamon-Elsevier Science Ltd2017

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Model-based optimization methods suffer from the limited accuracy of the available process models. Because of plant-model mismatch, model-based optimal inputs may be suboptimal or, worse, unfeasible for the plant. Modifier adaptation (MA) overcomes this ob ...

Elsevier2016

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We discuss optimal load sharing of parallel gas compressors in the presence of plant-model mismatch. We formulate this problem as a static real-time optimization task and propose to tackle it by means of modifier adaptation. Under mild assumptions, the cho ...

Ieee2016

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