Publications associées à Transthyrétine

Induction of cerebral beta-amyloidosis: Intracerebral versus systemic A beta inoculation

Despite the importance of the aberrant polymerization of A beta in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of A beta aggregation in vivo. Here we show that induction of cerebral beta-amyloidosis can be achie ...

National Academy of Sciences2009

Transmission and spreading of tauopathy in transgenic mouse brain

Tristan Bolmont

Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease(1). In the disease process, neuronal tau inclusions first appear in the transentorhinal cortex from where they se ...

Nature Publishing Group2009

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents

Hilal Lashuel, Adrian Schmid, Sonia Dos Santos, Marie-Stéphanie Camus

Several amyloid-forming proteins are characterized by the presence of hydrophobic and highly amyloidogenic core sequences that play critical roles in the initiation and progression of amyloid fibril formation. Therefore targeting these sequences represents ...

Wiley-Blackwell2008

The fold of alpha-synuclein fibrils

Henning Paul-Julius Stahlberg

The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases. In Parkinson's disease it is believed that the aggregation of a-synuclein (alpha-syn) from monomers by intermediates into amyloid fibrils is the toxic d ...

Proceedings of the National Academy of Sciences2008

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Hilal Lashuel, Ozgün Gökce, Mohammad Asad Jan Qureshi

Aggregation and fibril formation of amyloid-beta (Abeta) peptides Abeta40 and Abeta42 are central events in the pathogenesis of Alzheimer disease. Previous studies have established the ratio of Abeta40 to Abeta42 as an important factor in determining the f ...

American Society for Biochemistry and Molecular Biology2008

Substrate-targeting gamma-secretase modulators

Patrick Fraering

Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease ...

Nature Publishing Group2008

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

Lorène Aeschbach, Patrick Fraering, Hua Li

Gamma-secretase is an unconventional aspartyl protease that processes many type 1 membrane proteins within the lipid bilayer. Because its cleavage of amyloid-beta precursor protein generates the amyloid-beta protein (Abeta) of Alzheimer's disease, partiall ...

Wiley-Blackwell2008

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Hilal Lashuel, Adrian Schmid, Richard Alan Mimna, Marie-Stéphanie Camus

Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and cleara ...

2007

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation

Hilal Lashuel, David Viertl

The key pathogenic event in the onset of Alzheimer's disease (AD) is the aggregation of beta-amyloid (Abeta) peptides into toxic aggregates. Molecules that interfere with this process might act as therapeutic agents for the treatment of AD. The amino acid ...

Wiley-Blackwell2007

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Transthyrétine

Induction of cerebral beta-amyloidosis: Intracerebral versus systemic A beta inoculation

Transmission and spreading of tauopathy in transgenic mouse brain

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents

The fold of alpha-synuclein fibrils

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Substrate-targeting gamma-secretase modulators

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation

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Chattez avec Graph Search

Transmission and spreading of tauopathy in transgenic mouse brain

Substrate-targeting gamma-secretase modulators

Induction of cerebral beta-amyloidosis: Intracerebral versus systemic A beta inoculation

The fold of alpha-synuclein fibrils

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation

Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils