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Arnaud Comment

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Publications associées (73)

Ultra-High Field Birdcage Coils: a Comparison Study at 14.1T

Rolf Gruetter, Hongxia Lei, Tian Cheng, Arnaud Comment

An essential feature of magnetic resonance (MR) probes for magnetic resonance imaging and spectroscopy is the ability to generate uniform B-1(+) excitation in a volume of interest. When the magnetic field strength is increased, leading to an increase in re ...

Ieee2014

An apparatus for pulsed ESR and DNP experiments using optically excited triplet states down to liquid helium temperatures

Arnaud Comment, Sami Jannin, Jacques Van Der Klink, Tim Rolf Eichhorn, Martin Haag

In standard Dynamic Nuclear Polarization (DNP) electron spins are polarized at low temperatures in a strong magnetic field and this polarization is transferred to the nuclear spins by means of a microwave field. To obtain high nuclear polarizations cryogen ...

Academic Press Inc Elsevier Science2013

Methods for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements using long-lived states

Geoffrey Bodenhausen, Arnaud Comment, Sami Jannin, Paul Romeo Vasos, Riddhiman Sarkar

A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarized ...

2013

In vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by (13)C turnover from hyperpolarized [1-(13)C]acetate to [1-(13)C]acetylcarnitine

Rolf Gruetter, Mor-Miri Mishkovsky, João Miguel das Neves Duarte, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen

BACKGROUND: Acetate metabolism in skeletal muscle is regulated by acetylCoA synthetase (ACS). The main function of ACS is to provide cells with acetylCoA, a key molecule for numerous metabolic pathways including fatty acid and cholesterol synthesis and the ...

Elsevier Science Bv2013

Automated transfer and injection of hyperpolarized molecules with polarization measurement prior to in vivo NMR

Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen

Hyperpolarized magnetic resonance via dissolution dynamic nuclear polarization necessitates the transfer of the hyperpolarized molecules from the polarizer to the imager prior to in vivo measurements. This process leads to unavoidable losses in nuclear pol ...

2013

Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Yuhei Takado

Lactate plays an important role in brain energetics and is essential for neuronal function. Alteration of its metabolism might be associated with mechanisms linked to neurodegenerative disorders1. The purpose of this study was to demonstrate the potential ...

2013

A link between short-range and long-range properties of random sphere packings

Daniele Mari, Gérard Gremaud, Arnaud Comment, Riccardo Balzan, Alessandro Luigi Sellerio

We present a high precision particle-by-particle 3D reconstruction of granular systems composed of monodispersed spheres (sphere packings); the experimental approach is based on magnetic resonance imaging techniques. Our measurements revealed a strong corr ...

Springer Berlin Heidelberg2013

Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Mor-Miri Mishkovsky, Christophe Roussel, Andrea Capozzi, Jean-Noël Hyacinthe, Tian Cheng, Arnaud Comment, Najat Salameh, Yuhei Takado, Tim Rolf Eichhorn

Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure diagnosis and therapy monitoring through the detection of metabolic impairments in v ...

National Academy of Sciences2013

Over 35% liquid-state 13C polarization via dissolution dynamic nuclear polarization at 7 T and 1 K with ubiquitous nitroxyl radicals

Andrea Capozzi, Tian Cheng, Arnaud Comment, Yuhei Takado, Riccardo Balzan

The most versatile method to increase liquid-state 13C NMR sensitivity is dissolution dynamic nuclear polarization. The use of trityl radicals is usually required to obtain very large 13C polarization via this technique. We herein demonstrate that up to 35 ...

Royal Soc Chemistry2013

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment

The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observati ...

Nature Publishing Group2012

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