Horst Pick

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Publications associées (41)

The G protein coupled receptor CXCR4 designed by the QTY code becomes more hydrophilic and retains cell signaling activity

Horst Vogel, Horst Pick

G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facilitate GPCR studi ...

NATURE RESEARCH2020

Skin cell analysis

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Milica Jovic, Tzu-En Lin, Yingdi Zhu

The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected us ...

2020

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Horst Vogel, Horst Pick, Shuguang Yuan, Thamani Dahoun, Marc Brugarolas Campillos

The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants. Cognate agonists of most ORs have not yet been identified and potential non-olfactory processes m ...

Springer2019

MALDI Detection of Exosomes: A Potential Tool for Cancer Studies

Hubert Girault, Horst Pick, Natalia Gasilova, Tzu-En Lin, Yingdi Zhu

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry is used to detect intact whole exosomes, yielding exosomal fingerprints within minutes. This rapid exosome detection approach is proposed as a potential tool for cancer studies. M ...

2019

Tape-Stripping Electrochemical Detection of Melanoma

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin, Yingdi Zhu, Sorour Darvishi

A noninvasive electrochemical melanoma detection approach based on using adhesive tapes for collecting and fixing cells from a suspicious skin area and transferring the cells into a scanning electrochemical microscope (SECM) is presented. The adhesive laye ...

AMER CHEMICAL SOC2019

Detection of bacteria

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Milica Jovic, Yingdi Zhu

A method for bacteria detection and the assessment of the antimicrobial susceptibility profile uses a bacterial viability assay based on combining a highly efficient affinity bacteria enrichment/ separation with an electrochemical redox interrogation measu ...

2019

Single-Vesicle Assays Using Liposomes and Cell-Derived Vesicles: From Modeling Complex Membrane Processes to Synthetic Biology and Biomedical Applications

Horst Vogel, Horst Pick, Ana Catarina Rodrigues Alves

The plasma membrane is of central importance for defining the closed volume of cells in contradistinction to the extracellular environment. The plasma membrane not only serves as a boundary, but it also mediates the exchange of physical and chemical inform ...

AMER CHEMICAL SOC2018

Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

Bart Deplancke, Beat Fierz, Horst Pick, David Michael Suter, Cédric Deluz, Aurore Marie-France Delachat, Antonio Carlos Alves Meireles Filho, Nora Guidotti, Andreas Linus Bachmann, Carolin Christine Lechner

2018

Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry

Hubert Girault, Horst Pick, Natalia Gasilova, Liang Qiao, Milica Jovic, Yingdi Zhu

Titanium dioxide-modified target plates were developed to enhance intact bacteria analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The plates were designed to photocatalytically destroy the bacterial envelope struct ...

2018

Maldi device and methods of preparation and use thereof

Hubert Girault, Horst Pick, Liang Qiao, Milica Jovic, Yingdi Zhu

A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised pho ...

2018

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