Michaël Unser

Publications associées (516)

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Coupled Splines for Sparse Curve Fitting

Michaël Unser, Shayan Aziznejad, Thomas Jean Debarre

We formulate as an inverse problem the construction of sparse parametric continuous curve models that fit a sequence of contour points. Our prior is incorporated as a regularization term that encourages rotation invariance and sparsity. We prove that an op ...

2022

Opportunities and Challenges for Generative Adversarial Reconstruction by Distribution Matching (CryoGAN)

Michaël Unser, Pakshal Narendra Bohra

2022

Mechanical artifacts in optical projection tomography: classification and automatic calibration

Michaël Unser, Thanh-An Michel Pham, Jonathan Yuelin Dong, François Thierry M Marelli

Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However, various artifacts d ...

Optica Publishing Group2022

Diffraction Tomography from Single-Molecule Localization Microscopy: Numerical Feasibility

Michaël Unser, Thanh-An Michel Pham, Emmanuel Emilien Louis Soubies, Ferréol Arnaud Marie Soulez

Single-molecule localization microscopy (SMLM) is a fluorescence microscopy technique that achieves super-resolution imaging by sequentially activating and localizing random sparse subsets of fluorophores. Each activated fluorophore emits light that then s ...

IEEE2021

Optical diffraction tomography from single-molecule localization microscopy

Michaël Unser, Thanh-An Michel Pham, Emmanuel Emilien Louis Soubies, Ferréol Arnaud Marie Soulez

Single-molecule localization microscopy (SMLM) is a powerful method for the imaging of cellular structures. This modality delivers nanoscale resolution by sequentially activating a subset of fluorescent molecules and by extracting their super-resolved posi ...

2021

CryoGAN: A New Reconstruction Paradigm for Single-Particle Cryo-EM Via Deep Adversarial Learning

Michaël Unser, Laurène Donati, Harshit Gupta, Michael Thompson McCann

We present CryoGAN, a new paradigm for single-particle cryo-electron microscopy (cryo-EM) reconstruction based on unsupervised deep adversarial learning. In single-particle cryo-EM, the structure of a biomolecule needs to be reconstructed from a large set ...

2021

Principled Design and Implementation of Steerable Detectors

Michaël Unser, Zsuzsanna Püspöki, Julien René Pierre Fageot, Adrien Raphaël Depeursinge

We provide a complete pipeline for the detection of patterns of interest in an image. In our approach, the patterns are assumed to be adequately modeled by a known template, and are located at unknown positions and orientations that we aim at retrieving. W ...

2021

A constrained method for lensless coherent imaging of thin samples

Michaël Unser, Christophe Moser, Manon Rostykus

Lensless inline holography can produce high-resolution images over a large field of view (FoV). In a previous work [Appl. Opt.60, B38 (2021)], we showed that (i) the actual FoV can be extrapolated outside of the camera FoV and (ii) the effective resolution ...

2021

Convex optimization in sums of Banach spaces

Michaël Unser, Shayan Aziznejad

We characterize the solution of a broad class of convex optimization problems that address the reconstruction of a function from a finite number of linear measurements. The underlying hypothesis is that the solution is decomposable as a finite sum of compo ...

2021

Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features

Michaël Unser, Cathrin Brisken, Daniel Sage, Olivier Burri, Quentin Juppet, Fabio De Martino, Martin Weigert

Patient-Derived Xenografts (PDXs) are the preclinical models which best recapitulate inter- and intra-patient complexity of human breast malignancies, and are also emerging as useful tools to study the normal breast epithelium. However, data analysis gener ...

2021

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