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Martin Villiger

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Publications associées (32)

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Daniel Pawel Szlag, Corinne Berclaz, Jérôme Extermann, Joan Goulley

Aims/hypothesis It is generally accepted that structural and functional quantitative imaging of individual islets would be beneficial to elucidate the pathogenesis of type 1 diabetes. We here introduce functional optical coherence imaging (FOCI) for fast, ...
Springer Verlag2016

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Dimitri Nestor Alice Van De Ville, Theo Lasser, Anthony Christopher Davison, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Corinne Berclaz, Joan Goulley, Erica Martin-Williams

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...
2012

Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy

Theo Lasser, Christian Santschi, Christophe Pache, Martin Villiger, Arno Pino Bouwens, Noelia Laura Bocchio, Matthew Gibson, Corinne Berclaz, Joan Goulley

We introduce photothermal optical lock-in Optical Coherence Microscopy (poli-OCM), a volumetric imaging technique, which combines the depth sectioning of OCM with the high sensitivity of photothermal microscopy while maintaining the fast acquisition speed ...
Optical Society of America2012

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

Theo Lasser, Christophe Pache, Patrick Fraering, Martin Villiger, Arno Pino Bouwens, Tristan Bolmont, Mitko Dimitrov, Corinne Berclaz

We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β-amylo ...
Society for Neuroscience2012

Dark field optical coherence microscopy

Theo Lasser, Christophe Pache, Martin Villiger

The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. ...
2011

Extended Focus Optical Coherence Microscopy

Martin Villiger

Optical coherence tomography (OCT) is an interferometric imaging technique that can provide depth resolved cross-sectional views of biological tissue. OCT employs light with low temporal and yet high spatial coherence. The sample is illuminated point by po ...
EPFL2010

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...
Bentham Science Publishers2010

Dark-field optical coherence microscopy

Theo Lasser, Christophe Pache, Martin Villiger

Many solutions have been proposed to produce phase quantitative images of biological cell samples. Among these, Spectral Domain Phase Microscopy combines the fast imaging speed and high sensitivity of Optical Coherence Microscopy (OCM) in the Fourier domai ...
SPIE2010

Coherent transfer functions and extended depth of field

Theo Lasser, Christophe Pache, Rainer Leitgeb, Martin Villiger

To preserve the speed advantage of Fourier Domain detection in Optical Coherence Microscopy (OCM), extended depth of field is needed. With a narrow probing volume that extends over a long axial range, tissue could be measured in vivo and at cellular resolu ...
The International Society for Optical Engineering Spie-Int Soc Optical Engineering2010

Measurement of the coherent transfer function

Theo Lasser, Christophe Pache, Martin Villiger

It is important to characterize and quantify the imaging performance of optical coherence tomography (OCT) and especially optical coherence microscopy (OCM) systems for validation and calibration of the setup. We suggest using a simple rubber surface, pres ...
2010

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