Publications de Cédric Deluz | EPFL Graph Search

Orchestration of pluripotent stem cell genome reactivation during mitotic exit

David Michael Suter, Cédric Deluz, Ludovica Vanzan, Silja Michelle Placzek

Cell identity maintenance faces many challenges during mitosis, as most DNA-binding proteins are evicted from DNA and transcription is virtually abolished. How cells maintain their identity through division and faithfully re-initiate gene expression during ...

2025

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

David Michael Suter, Cédric Deluz, Torgil Elias Friman, Andrea Brigitta Alber, Subashika Govindan, Daniel Strebinger

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter f ...

2019

Mitotic chromosome binding predicts transcription factor properties in interphase

Cédric Deluz, David Michael Suter, Torgil Elias Friman, Andrea Brigitta Alber, Mahé Cécile Raccaud

Mammalian transcription factors (TFs) differ broadly in their nuclear mobility and sequence-specific/non-specific DNA binding. How these properties affect their ability to occupy specific genomic sites and modify the epigenetic landscape is unclear. The as ...

Nature Research2019

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

Bart Deplancke, David Michael Suter, Cédric Deluz, Vincent Roland Julien Gardeux, Antonio Carlos Alves Meireles Filho, Torgil Elias Friman, Subashika Govindan

The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewi ...

2019

Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

Bart Deplancke, Beat Fierz, Horst Pick, David Michael Suter, Cédric Deluz, Aurore Marie-France Delachat, Antonio Carlos Alves Meireles Filho, Nora Guidotti, Andreas Linus Bachmann, Carolin Christine Lechner

2018

Mitotic chromosome association predicts genome-wide transcription factor occupancy and impact on local chromatin accessibility

Cédric Deluz, David Michael Suter, Mahé Cécile Raccaud, Torgil Elias Friman, Andrea Brigitta Alber

MARY ANN LIEBERT, INC2018

Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions

Cédric Deluz, David Michael Suter, Subashika Govindan, Daniel Strebinger, Torgil Elias Friman, Andrea Brigitta Alber

MARY ANN LIEBERT, INC2018

OCT4 and SOX2 are required at the M-G1 transition to re-establish chromatin accessibility at enhancers in pluripotent stem cells

Cédric Deluz, David Michael Suter, Vincent Roland Julien Gardeux, Antonio Carlos Alves Meireles Filho, Torgil Elias Friman

MARY ANN LIEBERT, INC2018

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

Suliana Manley, Aleksandr Benke, David Michael Suter, Marion Leleu, Andrea Callegari, Cédric Deluz, Torgil Elias Friman, Mahé Cécile Raccaud, Daniel Strebinger

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles

Horst Vogel, Henning Paul-Julius Stahlberg, Cédric Deluz, Luigino Grasso, Ghérici Hassaïne

The function of membrane proteins is best understood if their structure in the lipid membrane is known. Here, we determined the structure of the mouse serotonin 5-HT3 receptor inserted in lipid bilayers to a resolution of 12 Å without stabilizing antibodie ...

Elsevier2016