Personne

Boris Hinz

Cette personne n’est plus à l’EPFL

Publications associées (40)

A method for assessing cell contraction includes adhering contractile cells to an oxidized and cellular adhesion activated surface of a biocompatible silicone elastomer film. The biocompatible silicone elastomer film allows the cells to contract and wrinkl ...

2017

Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants

Dominique Pioletti, Hicham Majd, Michael Friedrich, Boris Hinz, Silvio Ramondetti, Giorgio Pietramaggiori

Over the past decade, various implantable devices have been developed to treat diseases that were previously difficult to manage such diabetes, chronic pain, and neurodegenerative disorders. However, translation of these novel technologies into clinical pr ...

Elsevier2015

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Changes in the mechanical properties of dermis occur during skin aging or tissue remodeling and affect the activity of resident fibroblasts. With the aim to establish elastic culture substrates that reproduce the variable softness of dermis, we determined ...

Nature Publishing Group2014

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Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

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Triplet imaging is a novel optical technique that allows investigating oxy- gen metabolism at the single cell and the sub-cellular level. The method combines high temporal and spatial resolution, which are required for the monitoring of fast kinetics of ox ...

Springer Science+Business Media2012

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Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how ...

American Association for Cancer Research2011

The Single-Molecule Mechanics of the Latent TGF-beta 1 Complex

Jean-Jacques Meister, Boris Hinz, Lara Buscemi Estefanell, Aurélie Formey de Saint Louvent, Josiane Angèle Charlotte Smith-Clerc, David Ramonet Jimenez

Background: TGF-beta 1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-beta 1 binds to the latent TGF-beta 1-binding protein-1 (LTBP-1), whic ...

Elsevier2011

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

Boris Hinz, Lysianne Follonier Castella

Myofibroblast-induced remodeling of collagenous extracellular matrix is a key component of our body's strategy to rapidly and efficiently repair damaged tissues; thus myofibroblast activity is considered crucial in assuring the mechanical integrity of vita ...

Elsevier2010

Hypoxia Impairs Skin Myofibroblast Differentiation and Function

Boris Hinz, Giorgio Pietramaggiori

Ischemic wounds are characterized by oxygen levels lower than that of healthy skin ( hypoxia) and poor healing. To better understand the pathophysiology of impaired wound healing, we investigated how switching from high ( 21%) to low ( 2%) oxygen levels di ...

Nature Publishing Group2010

A New Lock-step Mechanism of Matrix Remodelling Based on Subcellular Contractile Events

Jean-Jacques Meister, Boris Hinz, Lara Buscemi Estefanell, Lysianne Follonier Castella

Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, Ca2+, contribute to myofibroblast contraction, we analysed both Ca2+ and subcellular contractio ...

Company of Biologists2010

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