Jörg Hülsken

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Publications associées (44)

The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

Jörg Hülsken

We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult he-matopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs ...

2020

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

Jörg Hülsken, Oliver Hantschel, Anja Irmisch

The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for γ ...

2019

Comprehensive analysis of cancer stemness

Jörg Hülsken

AMER ASSOC CANCER RESEARCH2018

Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

Jörg Hülsken, Paloma Ordonez Moran

The most prevalent single-nucleotide substitution (SNS) found in cancers is a C-to-T substitution in the CpG motif. It has been proposed that many of these SNSs arise during organismal aging, prior to transformation of a normal cell into a precancerous/can ...

2017

Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation

Jörg Hülsken, Zuzana Tatárová

Hematopoietic stem cell (HSC) transplantation represents a curative treatment for various hematological disorders. However, delayed reconstitution of innate and adaptive immunity often causes fatal complications. HSC maintenance and lineage differentiation ...

Cell Press2017

Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature

Bart Deplancke, Jörg Hülsken, Paloma Ordonez Moran, Petra Catalina Schwalie

A long-standing question in biology is whether multipotent somatic stem and progenitor cells (SSPCs) feature molecular properties that could guide their system-independent identification. Population-based transcriptomic studies have so far not been able to ...

Wiley2017

Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

Jörg Hülsken, Zuzana Tatárová

Functional analysis of primary tissue-specific stem cells is hampered by their rarity. Here we describe a greatly miniaturized microfluidic device for the multiplexed, quantitative analysis of the chemotactic properties of primary, bone marrow-derived mese ...

Royal Soc Chemistry2016

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

Christian Heinis, Jörg Hülsken, Pierre Vincent Dessen, Davide Bertoldo, Maola Khan Mohammad Golam

Upregulation of b-catenin, the primary mediator of the Wnt signaling pathway, plays an important role in the tumorigenesis of several types of human cancer. Targeting b-catenin to interfere with its ability to serve as a translational co-activator is consi ...

2016

Phage selection of chemically stabilized alpha-helical peptide ligands

Christian Heinis, Jörg Hülsken, Pierre Vincent Dessen, Philippe Diderich, Davide Bertoldo, Maola Khan Mohammad Golam

Short alpha-helical peptides stabilized by linkages between constituent amino acids offer an attractive format for ligand development. In recent years, a range of excellent ligands based on stabilized alpha-helices were generated by rational design using a ...

2016

Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host

Jörg Hülsken, Pierre Vincent Dessen, Patrick Schmidt, Nancy Thompson, Nicolas Pierre Desbaillets

Amer Assoc Cancer Research2016

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Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature

Bart Deplancke, Jörg Hülsken, Paloma Ordonez Moran, Petra Catalina Schwalie

Wiley2017

Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation

Jörg Hülsken, Zuzana Tatárová

Cell Press2017

Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

Jörg Hülsken, Zuzana Tatárová

Royal Soc Chemistry2016

Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host

Jörg Hülsken, Pierre Vincent Dessen, Patrick Schmidt, Nancy Thompson, Nicolas Pierre Desbaillets

Amer Assoc Cancer Research2016