Sean Lewis Hill

Publications associées (41)

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Computational Neuroscience Ontology: a new tool to provide semantic meaning to your models

Sean Lewis Hill

The diversity of modeling approaches in computational neuroscience makes model sharing, retrieval, reuse and reproducibility difficult and even sometimes impossible. To address this problem, standardized languages have been developed by and for the communi ...

2012

A neuron membrane mesh representation for visualization of electrophysiological simulations

Henry Markram, Sean Lewis Hill, Felix Schürmann, Juan Bautista Hernando Vieites, Sébastien Lasserre

We present a process to automatically generate three-dimensional mesh representations of the complex, arborized cell membrane surface of cortical neurons (the principal information processing cells of the brain) from nonuniform morphological measurements. ...

Institute of Electrical and Electronics Engineers2012

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Henry Markram, Sean Lewis Hill, Felix Schürmann, Idan Segev

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling ...

2011

NineML: the network interchange for neuroscience modeling language

Sean Lewis Hill, Eilif Benjamin Muller, Michael Lee Hines

The growing number of large-scale neuronal network models has created a need for standards and guidelines to ease model sharing and facilitate the replication of results across different simulators. To foster community efforts towards such standards, the I ...

2011

Effective Stimuli for Constructing Reliable Neuron Models

Henry Markram, Sean Lewis Hill, Thomas Berger, Felix Schürmann, Idan Segev

The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for ...

2011

Modeling the effects of midazolam on cortical and thalamic neurons

Sean Lewis Hill

Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling ...

2009

Modeling the Gabaergic Action of Etomidate on the Thalamocortical System

Sean Lewis Hill

BACKGROUND: We have used a computational model of the thalamocortical system to investigate the effects of a GABAergic anesthetic (etomidate) on cerebral cortical and thalamic neuronal function. We examined the effects of phasic an tonic inhibition, as wel ...

2009

A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON

Henry Markram, Sean Lewis Hill, Felix Schürmann, Michael Lee Hines

As neuronal simulations approach larger scales with increasing levels of detail, the neurosimulator software represents only a part of a chain of tools ranging from setup, simulation, interaction with virtual environments to analysis and visualizations. Pr ...

2009

Breakdown of Effective Connectivity During Slow Wave Sleep: Investigating the Mechanism Underlying a Cortical Gate Using Large-Scale Modeling

Sean Lewis Hill

Esser SK, Hill S, Tononi G. Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling. J Neurophysiol 102: 2096-2111, 2009. First published August 5, 2009; doi: 10.1152/jn. ...

2009

Sleep improves the variability of motor performance

Sean Lewis Hill

Sleep after learning often enhances task performance, but the underlying mechanisms remain unclear. Using a well-characterized rotation learning paradigm implemented both behaviorally and in computer simulations, we compared two main hypotheses: the first, ...

2008

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Breakdown of Effective Connectivity During Slow Wave Sleep: Investigating the Mechanism Underlying a Cortical Gate Using Large-Scale Modeling

Sean Lewis Hill

2009