Publications de Paul James Marchand

Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal

Microvascular stalling, the process occurring when a capillary temporarily loses perfusion, has gained increasing interest in recent years through its demonstrated presence in various neuropathologies. Studying the impact of such stalls on the surrounding ...

2023

Soliton microcomb based spectral domain optical coherence tomography

Tobias Kippenberg, Theo Lasser, Paul James Marchand, Junqiu Liu, Martin Hubert Peter Pfeiffer

Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic ...

Nature Research2021

Supervised learning to quantify amyloidosis in whole brains of an Alzheimer's disease mouse model acquired with optical projection tomography

Dimitri Nestor Alice Van De Ville, Theo Lasser, Aleksandra Radenovic, Paul James Marchand, Arielle Louise Planchette, Virginie Sophie Uhlmann, David Nguyen

Alzheimer's disease (AD) is characterized by amyloidosis of brain tissues. This phenomenon is studied with genetically-modified mouse models. We propose a method to quantify amyloidosis in whole 5xFAD mouse brains, a model of AD. We use optical projection ...

2019

Structural and functional brain imaging using extended-focus optical coherence tomography and microscopy

Paul James Marchand

Neuroimaging techniques aim at revealing the anatomy and functional organisation of cerebral structures. Over the past decades, functional magnetic resonance imaging (fMRI) has revolutionized our understanding of human cerebral physiology through its abili ...

EPFL2018

Imaging of cortical structures and microvasculature using extended-focus optical coherence tomography at 1.3 mu m

Theo Lasser, Paul James Marchand, Arno Pino Bouwens, Daniel Pawel Szlag, Damien Nguyen

2018

In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range

Theo Lasser, Paul James Marchand, Arno Pino Bouwens, Daniel Pawel Szlag

SPIE Society of Photo-optical Instrumentation Engineers2018

Massively parallel data processing for quantitative total flow imaging with optical coherence microscopy and tomography

Theo Lasser, Paul James Marchand, Daniel Pawel Szlag, Marcin Antoni Sylwestrzak

We present an application of massively parallel processing of quantitative flow measurements data acquired using spectral optical coherence microscopy (SOCM). The need for massive signal processing of these particular datasets has been a major hurdle for m ...

Elsevier2017

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

Johan Auwerx, Theo Lasser, Laurent Mouchiroud, Paul James Marchand, Arno Pino Bouwens, Vincenzo Sorrentino, Séverine Coquoz, Daniel Pawel Szlag

Fast, label-free, high-resolution, three-dimensional imaging platforms are crucial for high-throughput in vivo time-lapse studies of the anatomy of Caenorhabditis elegans, one of the most commonly used model organisms in biomedical research. Despite the ne ...

Public Library of Science2017

Optical projection tomography for rapid whole mouse brain imaging

Theo Lasser, Dimitri Nestor Alice Van De Ville, Jessica Sordet, Paul James Marchand, Arielle Louise Planchette, David Nguyen, Miguel Sison, Jérôme Extermann, Antonio Lopez, Marcin Antoni Sylwestrzak

In recent years, three-dimensional mesoscopic imaging has gained significant importance in life sciences for fundamental studies at the whole-organ level. In this manuscript, we present an optical projection tomography (OPT) method designed for imaging of ...

Optical Soc Amer2017

Interferometric synthetic aperture microscopy for extended focus optical coherence microscopy

Theo Lasser, Paul James Marchand, Arno Pino Bouwens, Jérôme Extermann, Séverine Coquoz

Optical coherence microscopy (OCM) is an interferometric technique providing 3D images of biological samples with micrometric resolution and penetration depth of several hundreds of micrometers. OCM differs from optical coherence tomography (OCT) in that i ...

2017