Publications de Urs Alexander Müller

Low-Noise, High-Density Microelectronics for Multi-Mode Screening of Excitable Biological Cells

In the past decades, two recording tools have established themselves as the working horses in the field of electrophysiological cell research: the microelectrode array (MEA) and the optical fluorescence imaging. The former is a grid of miniature electrodes ...

EPFL2012

Low-noise amplifier with sample & hold for high-density stimulation and recording of neural signals

Pierre-André Farine, Steve Tanner, Urs Alexander Müller

In this paper, the design of a low-noise amplifier (LNA) for a 32x32 pixel microelectrode array (MEA) is presented. Its gain and noise amount to 50 dB and 10 μVrms, respectively, at a bandwidth of 66 kHz. The LNA consumes less than 85 μW. The integrated of ...

2011

A glass-based, high density microelectrode array (MEA) with integrated CMOS amplification

Pierre-André Farine, Steve Tanner, Mohssen Moridi, Urs Alexander Müller

A new bio-interface for active MEAs is presented in this paper. Unlike standard approaches that deposit MEA electrodes using post-processing of the integrated circuit, the proposed structure is based on Ti/Pt microelectrodes inserted by microfabrication in ...

2011

Fully differential low-noise amplifier with offset reduction for high-resolution neural signal recording

Pierre-André Farine, Steve Tanner, Urs Alexander Müller

A prototype of a high-density multielectrode array for in vitro recording of electrogenic cell networks has been developed. On a surface of 1.92x1.92mm2, it includes 32x32 pixels with a dimension of 60x60µm2. For local amplification of the sensed extracell ...

2010